H
Hena R. Ashar
Researcher at Schering-Plough
Publications - 4
Citations - 983
Hena R. Ashar is an academic researcher from Schering-Plough. The author has contributed to research in topics: Farnesyl Transferase Inhibitor & Prenylation. The author has an hindex of 4, co-authored 4 publications receiving 966 citations.
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Journal ArticleDOI
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
Asra Mirza,Marnie McGuirk,Tish Hockenberry,Qun Wu,Hena R. Ashar,Stuart Black,Shu Fen Wen,Luquan Wang,Paul Kirschmeier,W. Robert Bishop,Loretta L. Nielsen,Cecil B. Pickett,Suxing Liu +12 more
TL;DR: It is shown that wild-type p53 represses survivin expression at both mRNA and protein levels, suggesting that loss of survivin mediates, at least, in part the p53-dependent apoptotic pathway.
Journal ArticleDOI
Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.
Hena R. Ashar,Linda James,Kimberly Gray,Donna Carr,Stuart Black,Lydia Armstrong,W. Robert Bishop,Paul Kirschmeier +7 more
TL;DR: The results imply that the inhibition of CENP-E farnesylation results in the alteration of the microtubule-centromere interaction during mitosis and results inThe accumulation of cells prior to metaphase.
Journal ArticleDOI
The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines
Hena R. Ashar,Linda James,Kimberly Gray,Donna Carr,Marnie McGuirk,Eugene Maxwell,Stuart Black,Lydia Armstrong,Doll Ronald J,Taveras Arthur G,W. Robert Bishop,Paul Kirschmeier +11 more
TL;DR: Experiments show that SCH 66336 altered the cell cycle distribution of sensitive human tumor cells in two distinct ways, and suggest that cell cycle effects, either G(1) or G(2)-->M accumulation, and p53 status are important for mediating the effects of FTIs on tumor cells.