S
Suxing Liu
Researcher at Schering-Plough
Publications - 26
Citations - 2477
Suxing Liu is an academic researcher from Schering-Plough. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 13, co-authored 20 publications receiving 2370 citations. Previous affiliations of Suxing Liu include Merck & Co..
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Journal ArticleDOI
Genomic targets of the human c-Myc protein
Paula C. Fernandez,Scott R. Frank,Luquan Wang,Marianne Schroeder,Suxing Liu,Jonathan R. Greene,Andrea Cocito,Bruno Amati +7 more
TL;DR: A large-scale screen for genomic Myc-binding sites in live human cells is presented and points to a high regulatory and biological diversity among MyC-target genes.
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Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
Asra Mirza,Marnie McGuirk,Tish Hockenberry,Qun Wu,Hena R. Ashar,Stuart Black,Shu Fen Wen,Luquan Wang,Paul Kirschmeier,W. Robert Bishop,Loretta L. Nielsen,Cecil B. Pickett,Suxing Liu +12 more
TL;DR: It is shown that wild-type p53 represses survivin expression at both mRNA and protein levels, suggesting that loss of survivin mediates, at least, in part the p53-dependent apoptotic pathway.
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Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
Asra Mirza,Qun Wu,Luquan Wang,Terri McClanahan,W. Robert Bishop,Ferdous Gheyas,Wei Ding,Beth Hutchins,Tish Hockenberry,Paul Kirschmeier,Jonathan R. Greene,Suxing Liu +11 more
TL;DR: A small-scale quantitative chromatin immunoprecipitation analysis indicated that in vivo p53–DNA interaction was detected in eight out of 10 genes, suggesting that a portion of p53 target genes in the human genome could be negatively regulated by p53 via sequence-specific DNA binding.
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Differential effects of cell cycle regulatory protein p21WAF1/Cip1 on apoptosis and sensitivity to cancer chemotherapy
TL;DR: It is shown that p21(WAF1/Cip1) can assume both pro- or anti-apoptotic functions in response to anti-tumor agents depending on cell type and cellular context.
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Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches
Luquan Wang,Qun Wu,Ping Qiu,Asra Mirza,Marnie McGuirk,Paul Kirschmeier,Jonathan R. Greene,Yaolin Wang,Cecil B. Pickett,Suxing Liu +9 more
TL;DR: A novel approach to analysis of global gene regulatory network through the integration of human genomic sequence information and genome-wide gene expression analysis is illustrated.