Eugene Maxwell

TL;DR: A Staphylococcus aureus antisense knockdown strategy is adapted to genetically identify the cell division Z ring components—FtsA, FtsZ, and FtsW—as β-lactam susceptibility determinants of methicillin-resistant S. aureUS to support a target-based approach to develop synergistic drug combinations to combat MRSA with improved efficacy and reduced potential for drug resistance.

TL;DR: It is demonstrated that echistatin binding to α vβ 3 is of high affinity and irreversible similar to vitronectin and provides an alternate ligand for high-throughput screening for α v β 3 antagonists.

TL;DR: Experiments show that SCH 66336 altered the cell cycle distribution of sensitive human tumor cells in two distinct ways, and suggest that cell cycle effects, either G(1) or G(2)-->M accumulation, and p53 status are important for mediating the effects of FTIs on tumor cells.

TL;DR: neutralizing antibodies against IGFR1 represent a valid approach to inhibit growth of tumor cells and inhibited the growth of MCF7 cells in soft agar.

TL;DR: In vitro proliferation of human and mouse tumor cells expressing high levels of activated/phosphorylated Akt was inhibited by both Akt-DN and p53, in comparison with control viruses expressing beta-galactosidase and empty virus.