H
Henglei Lu
Researcher at Chinese Academy of Sciences
Publications - 22
Citations - 332
Henglei Lu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 15 publications receiving 196 citations. Previous affiliations of Henglei Lu include Shanghai University.
Papers
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Journal ArticleDOI
Hypoglycemic effect of the total flavonoid fraction from Folium Eriobotryae
TL;DR: The antidiabetic effect of the total flavonoids fraction from leaves of Eriobotrya japonica was evaluated through normal and streptozotocin-induced diabetic mice and suggested that EJF has hypoglycemic potential.
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Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae.
Henglei Lu,Ji-Jun Chen,Wen-Yong Li,Bingru Ren,J.L. Wu,H.Y. Kang,Haotian Zhang,An Adams,N. De Kimpe +8 more
TL;DR: The evidences indicated that the total triperpene acid fraction from Folium Eriobotryae has a high anti-diabetic potential along with a good hypolipidemic profile.
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18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Shou-yan Wu,Cui Shichao,Le Wang,Yi-ting Zhang,Xiao-xia Yan,Henglei Lu,Guozhen Xing,Jin Ren,Likun Gong +8 more
TL;DR: 18b-GA confers hepatoprotection against ANIT-induced cholestasis by activating FXR through Sirt1, which promotes gene expression of the efflux transporter, and consequently attenuates dysregulation of bile acid homeostasis in hepatocyte compartments.
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Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy
Huijie Guo,Huijie Guo,Mei Pu,Mei Pu,Yusi Tai,Yuxiang Chen,Henglei Lu,Junwen Qiao,Guanghui Wang,Jing Chen,Xinming Qi,Ruimin Huang,Zhouteng Tao,Jin Ren,Jin Ren +14 more
TL;DR: In vitro and in vivo data indicate that miR-30b-5p may inhibit the TFEB-dependent transactivation by binding to the CLEAR elements in the nucleus to regulate the lysosomal biogenesis and autophagy.
Journal ArticleDOI
miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder.
Lei Fan,Rongtao Lai,Ningning Ma,Yunxia Dong,Yu Li,Qian Wu,Junwen Qiao,Henglei Lu,Likun Gong,Zhouteng Tao,Jing Chen,Qing Xie,Jin Ren,Jin Ren +13 more
TL;DR: The mechanism of miR-552-3p modulating LXRα and FXR provided a new mode of miRNA-mediated gene regulation and suggested that it might be a potential therapeutic target for the treatment of glycolipid metabolic disease.