H
Henk J. ter Laak
Researcher at Radboud University Nijmegen
Publications - 32
Citations - 1341
Henk J. ter Laak is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Muscular dystrophy & Muscle biopsy. The author has an hindex of 18, co-authored 31 publications receiving 1286 citations. Previous affiliations of Henk J. ter Laak include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity.
Jan van Deursen,Arend Heerschap,Frank Oerlemans,Wim Rultenbeek,Paul H.K. Jap,Henk J. ter Laak,Bé Wieringa +6 more
TL;DR: Strikingly, PCr levels decline normally during muscle exercise, suggesting that M-CK-mediated conversion is not the only route for PCr utilization in active muscle.
Journal ArticleDOI
Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins
Marina A. Schwab,Sven W. Sauer,Jürgen G. Okun,Leo G.J. Nijtmans,Richard J. Rodenburg,Lambert P. van den Heuvel,Stefan Dröse,Ullrich Brandt,Georg F. Hoffmann,Henk J. ter Laak,Stefan Kölker,Jan A.M. Smeitink +11 more
TL;DR: The results favour the hypothesis that toxic metabolites, in particular propionyl-CoA, are involved in the pathogenesis of inherited disorders of propionate metabolism, sharing mechanistic similarities with Propionate toxicity in micro-organisms.
Journal ArticleDOI
Congenital muscular dystrophy.
Q.H. Leyten,Fons J. M. Gabreëls,Willy O. Renier,Henk J. ter Laak,Rob C.A. Sengers,Reinier A. Mullaart +5 more
TL;DR: In this paper, the authors report the cases of 18 patients with CMD, six of whom also have involvement of the central nervous system, corresponding to the Fukuyama type of CMD.
Journal ArticleDOI
Multiple oxidative phosphorylation deficiencies in severe childhood multi-system disorders due to polymerase gamma (POLG1) mutations.
Maaike de Vries,Richard J. Rodenburg,Eva Morava,Edwin P. M. van Kaauwen,Henk J. ter Laak,Reinier A. Mullaart,Irina N. Snoeck,Peter M. van Hasselt,Peter Harding,Lambert P. van den Heuvel,Jan A.M. Smeitink +10 more
TL;DR: Performing POLG1 mutation analysis in children with combined oxidative phosphorylation deficiencies in muscle, even if the clinical picture is not Alpers syndrome, is suggested.
Journal ArticleDOI
Myotonic dystrophy kinase is a component of neuromuscular junctions
Peter F.M. van der Ven,G Jansen,Toln H.M.S.M.van Kuppevelt,M. Benjamin Perryman,Mark Lupa,Patrick W. Dunne,Henk J. ter Laak,Paul H.K. Jap,Jacques H. Veerkamp,Henry F. Epstein,Bé Wieringa +10 more
TL;DR: The development of antisera against synthetic DM-PK peptide antigens and their use in biochemical and histochemical studies provide a basis for further characterisation of the role of the kinase in protein assembly processes or signal mediation at synaptic sites and ultimately for the understanding of the complex pathophysiology of DM.