Journal ArticleDOI
Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity.
Jan van Deursen,Arend Heerschap,Frank Oerlemans,Wim Rultenbeek,Paul H.K. Jap,Henk J. ter Laak,Bé Wieringa +6 more
TLDR
Strikingly, PCr levels decline normally during muscle exercise, suggesting that M-CK-mediated conversion is not the only route for PCr utilization in active muscle.About:
This article is published in Cell.The article was published on 1993-08-27. It has received 331 citations till now. The article focuses on the topics: Phosphocreatine & Creatine kinase.read more
Citations
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Journal ArticleDOI
Creatine and Creatinine Metabolism
Markus Wyss,Rima Kaddurah-Daouk +1 more
TL;DR: A comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism is presented, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology.
Journal ArticleDOI
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Stephan Teglund,Catriona McKay,Erin G. Schuetz,Jan M. van Deursen,Dimitrios J. Stravopodis,Demin Wang,Michael Brown,Sara Bodner,Gerard Grosveld,James N. Ihle,James N. Ihle +10 more
TL;DR: The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin.
Journal ArticleDOI
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
William E. Thierfelder,J. M. Van Deursen,K. Yamamoto,Ralph A. Tripp,S. R. Sarawar,R. T. Carson,Mark Y. Sangster,Dario A. A. Vignali,Peter C. Doherty,G. C. Grosveld,James N. Ihle +10 more
TL;DR: All IL-12 functions tested were disrupted, including the induction of IFN-γ, mitogenesis, enhancement of natural killer cytolytic function and Thl differentiation.
Journal ArticleDOI
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Evan Parganas,Demin Wang,Dimitrios J. Stravopodis,David J. Topham,Jean-Christophe Marine,Stephan Teglund,Elio F. Vanin,Sara Bodner,Oscar R. Colamonici,Jan M. van Deursen,Gerard Grosveld,James N. Ihle +11 more
TL;DR: Reconstitution experiments demonstrate that Jak2 is not required for the generation of lymphoid progenitors, their amplification, or functional differentiation, and plays a critical, nonredundant role in the function of a specific group of cytokines receptors.
Journal ArticleDOI
Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy
Stefan Neubauer,Michael Horn,Monika Cramer,Kerstin Harre,John B. Newell,Werner Peters,Thomas Pabst,Georg Ertl,Dietbert Hahn,Joanne S. Ingwall,Kurt Kochsiek +10 more
TL;DR: The myocardial phosphocreatine-to-ATP ratio, measured noninvasively with 31P-MR spectroscopy, is a predictor of both total and cardiovascular mortality in patients with dilated cardiomyopathy.
References
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Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
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Histopathologic technic and practical histochemistry.
TL;DR: Histopathologies technic and practical histochemistry, Histopathologie techno-practical histochemistry and the role of nanofiltration in medicine and drug discovery and abuse are studied.
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Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI