H
Henry Yip
Researcher at Bristol-Myers Squibb
Publications - 6
Citations - 41
Henry Yip is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Supercritical fluid chromatography & Ammonium acetate. The author has an hindex of 1, co-authored 6 publications receiving 13 citations.
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Journal ArticleDOI
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
Ashvinikumar V. Gavai,Derek J. Norris,George V. Delucca,David R. Tortolani,John S. Tokarski,Dharmpal S. Dodd,Daniel O'malley,Yufen Zhao,Claude A. Quesnelle,Patrice Gill,Wayne Vaccaro,Tram N. Huynh,Vijay T. Ahuja,Wen-Ching Han,Mussari Christopher P,Lalgudi S. Harikrishnan,Muthoni G. Kamau,Michael A. Poss,Steven Sheriff,Chunhong Yan,Frank Marsilio,Krista Menard,Mei-Li Wen,Richard Rampulla,Dauh-Rurng Wu,Jianqing Li,Huiping Zhang,Peng Li,Dawn Sun,Henry Yip,Sarah C. Traeger,Yingru Zhang,Arvind Mathur,Haiying Zhang,Christine Huang,Zheng Yang,Asoka Ranasinghe,Gerry Everlof,Nirmala Raghavan,Ching Kim Tye,Susan Wee,John T. Hunt,Gregory D. Vite,Richard A. Westhouse,Francis Y. Lee +44 more
TL;DR: In this article, a combination of structure-activity relationship and protein structure-guided drug design led to the discovery of a differently oriented carbazole 9 with favorable binding to the tryptophan, proline, and phenylalanine (WPF) shelf conserved in the BET family.
Proceedings ArticleDOI
Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer
Ashvinikumar V. Gavai,Derek J. Norris,David R. Tortolani,Daniel O'malley,Yufen Zhao,Claude A. Quesnelle,Patrice Gill,Wayne Vaccaro,Tram N. Huynh,Vijay T. Ahuja,Dharmpal S. Dodd,Mussari Christopher P,Lalgudi S. Harikrishnan,Muthoni G. Kamau,Tokarski John S,Steven Sheriff,Richard Rampulla,Dauh-Rurng Wu,Jianqing Li,Huiping Zhang,Peng Li,Dawn Sun,Henry Yip,Yingru Zhang,Arvind Mathur,Haiying Zhang,Christine Huang,Zheng Yang,Asoka Ranasinghe,Celia D’Arienzo,Ching Su,Gerry Everlof,Lisa Zhang,Nirmala Raghavan,John T. Hunt,Michael A. Poss,Gregory D. Vite,Richard A. Westhouse,Susan Wee +38 more
TL;DR: Crystal structure and subsequent SAR studies demonstrated that the isoxazole moiety formed critical interactions with the BET bromodomains and led to the identification of BMS-986158, which demonstrated in vitro and in vivo potency against a variety of tumor types.
Journal ArticleDOI
Large-scale supercritical fluid chromatography purification of unstable STING agonist intermediates.
Dawn Sun,Dauh-Rurng Wu,Peng Li,Henry Yip,Bei Wang,Xiaoping Hou,Rulin Zhao,Huiping Zhang,James Kempson,Arvind Mathur +9 more
TL;DR: In this paper, a prepartitioned supercritical fluid chromatography (SFC) was used to obtain the desired regioisomer as a key intermediate in a STING agonist program.
Journal ArticleDOI
The effect of water on the large-scale supercritical fluid chromatography purification of two factor XIa active pharmaceutical ingredients.
Peng Li,Dauh-Rurng Wu,Henry Yip,Dawn Sun,Huiping Zhang,Xiaoping Hou,James Kempson,Arvind Mathur +7 more
TL;DR: In this paper, two steps of supercritical fluid chromatography (SFC) were developed for the chiral resolution of the penultimate and achiral purification of final active pharmaceutical ingredient (API), BMS-962212.