Heriberto Acosta

TL;DR: Factors contributing to the lower risk effect in the ApoE gene ε4 allele are likely due to ancestry-specific genetic factors near ApOE rather than non-genetic ethnic, cultural, and environmental factors.

TL;DR: The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers and leads to a better understanding of genetic risk for AD among this population.

TL;DR: The Puerto Rico Alzheimer Disease Initiative (PRADI) is a Multisource Ascertainment Approach that aims to provide a single source of information for diagnosis and treatment of Alzheimer's disease through a multi-modal approach.

TL;DR: This paper identified genetic variants for AD through a family-based design using the Puerto Rican (PR) Alzheimer Disease Initiative (PRADI) using whole-genome sequencing (WGS) and parametric linkage analysis.

TL;DR: Findings in multiplex Caribbean Hispanic Puerto Rican families to identify rare causal variants influencing Alzheimer disease through linkage and segregation-based approaches indicates the critical role of rare variation in Alzheimer disease etiology.