P
Parker Bussies
Researcher at University of Miami
Publications - 14
Citations - 222
Parker Bussies is an academic researcher from University of Miami. The author has contributed to research in topics: Population & Endometrial cancer. The author has an hindex of 5, co-authored 13 publications receiving 124 citations. Previous affiliations of Parker Bussies include John P. Hussman Institute for Human Genomics.
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Journal ArticleDOI
Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
Farid Rajabli,Briseida E. Feliciano,Katrina Celis,Kara L. Hamilton-Nelson,Patrice L. Whitehead,Larry D. Adams,Parker Bussies,Clara P. Manrique,Alejandra Rodriguez,Vanessa C. Rodriguez,Takiyah D. Starks,Grace Byfield,Carolina B. Sierra Lopez,Jacob L. McCauley,Heriberto Acosta,Angel Chinea,Brian W. Kunkle,Christiane Reitz,Lindsay A. Farrer,Gerard D. Schellenberg,Badri N. Vardarajan,Jeffery M. Vance,Jeffery M. Vance,Michael L. Cuccaro,Michael L. Cuccaro,Eden R. Martin,Eden R. Martin,Jonathan L. Haines,Goldie S. Byrd,Gary W. Beecham,Gary W. Beecham,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance +32 more
TL;DR: Factors contributing to the lower risk effect in the ApoE gene ε4 allele are likely due to ancestry-specific genetic factors near ApOE rather than non-genetic ethnic, cultural, and environmental factors.
Journal ArticleDOI
BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Matthew G. Field,Jeffim N. Kuznetsov,Parker Bussies,Louie Z. Cai,Karam A. Alawa,Christina L. Decatur,Stefan Kurtenbach,J. William Harbour +7 more
TL;DR: This study suggests that the initial event in the divergence of Class 2 UM from Class 1 UM is loss of one copy of chromosome 3, followed by mutation of BAP1 on the remaining copy of chromosomes 3, leading to the methylomic repatterning profile characteristic of Class2 UMs.
Journal ArticleDOI
Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds
Anthony J. Griswold,Anthony J. Griswold,Katrina Celis,Parker Bussies,Farid Rajabli,Patrice L. Whitehead,Kara L. Hamilton-Nelson,Gary W. Beecham,Gary W. Beecham,Derek M. Dykxhoorn,Derek M. Dykxhoorn,Karen Nuytemans,Karen Nuytemans,Liyong Wang,Liyong Wang,Olivia K. Gardner,Daniel A. Dorfsman,Eileen H. Bigio,M.-Marsel Mesulam,Sandra Weintraub,Changiz Geula,Marla Gearing,Elisa Mcgrath-Martinez,Clifton L. Dalgard,William K. Scott,William K. Scott,Jonathan L. Haines,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Juan I. Young,Juan I. Young,Jeffery M. Vance,Jeffery M. Vance +32 more
TL;DR: In this paper, single-nucleus RNA sequencing was performed on frozen frontal cortex of homozygous APOE e4/e4 AD patients: seven with African local genomic ancestry (ALA), four with ALA, and a total of 60,908 nuclei were sequenced.
Journal ArticleDOI
Use of local genetic ancestry to assess TOMM40-523' and risk for Alzheimer disease.
Parker Bussies,Farid Rajabli,Anthony J. Griswold,Daniel A. Dorfsman,Patrice L. Whitehead,Larry D. Adams,Pedro Ramon Mena,Michael L. Cuccaro,Jonathan L. Haines,Goldie S. Byrd,Gary W. Beecham,Margaret A. Pericak-Vance,Juan I. Young,Jeffery M. Vance +13 more
TL;DR: This study confirms previous reports that increasing allele length of the TOMM40-523′ repeat is associated with decreased risk for LOAD in carriers of homozygous APOE ε3 alleles and demonstrates that this effect is occurring in those individuals with the EUR LGA APOEε3 allele haplotype.
Journal ArticleDOI
The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach.
Briseida E. Feliciano-Astacio,Katrina Celis,Jairo Ramos,Farid Rajabli,Larry D. Adams,Alejandra Rodriguez,Vanessa C. Rodriguez,Parker Bussies,Carolina Sierra,Patricia Manrique,Pedro Ramon Mena,Antonella Grana,Michael Prough,Kara L. Hamilton-Nelson,Nereida I. Feliciano,Angel Chinea,Heriberto Acosta,Jacob L. McCauley,Jeffery M. Vance,Gary W. Beecham,Margaret A. Pericak-Vance,Michael L. Cuccaro +21 more
TL;DR: The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers and leads to a better understanding of genetic risk for AD among this population.