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Kara L. Hamilton-Nelson
Researcher at University of Miami
Publications - 81
Citations - 9080
Kara L. Hamilton-Nelson is an academic researcher from University of Miami. The author has contributed to research in topics: Biology & Genome-wide association study. The author has an hindex of 26, co-authored 58 publications receiving 7204 citations. Previous affiliations of Kara L. Hamilton-Nelson include John P. Hussman Institute for Human Genomics & Case Western Reserve University.
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Journal ArticleDOI
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Jean-Charles Lambert,Jean-Charles Lambert,Jean-Charles Lambert,Carla A. Ibrahim-Verbaas,Denise Harold,Adam C. Naj,Rebecca Sims,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Gyungah Jun,Anita L. DeStefano,Joshua C. Bis,Gary W. Beecham,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A. Thornton-Wells,Nicola Jones,Albert V. Smith,Vincent Chouraki,Vincent Chouraki,Vincent Chouraki,Charlene Thomas,M. Arfan Ikram,Diana Zelenika,Badri N. Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Amy Gerrish,Helena Schmidt,Brian W. Kunkle,Melanie L. Dunstan,Agustín Ruiz,Marie-Thérèse Bihoreau,Seung Hoan Choi,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Alfredo Ramirez,Olivier Hanon,Annette L. Fitzpatrick,Joseph D. Buxbaum,Dominique Campion,Paul K. Crane,Clinton T. Baldwin,Tim Becker,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga,David Craig,Najaf Amin,Claudine Berr,Oscar L. Lopez,Philip L. De Jager,Philip L. De Jager,Vincent Deramecourt,Janet A. Johnston,Denis A. Evans,Simon Lovestone,Luc Letenneur,Francisco J. Morón,David C. Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Kristel Sleegers,Alison Goate,Nathalie Fievet,Nathalie Fievet,Matthew J. Huentelman,Michael Gill,Kristelle Brown,M. Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B. Larson,Eric B. Larson,Robert C. Green,Amanda J. Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Peter St George-Hyslop,Jordi Clarimón,Alberto Lleó,Anthony Bayer,Debby W. Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petroula Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez-Garcia,Nick C. Fox,John Hardy,Maria Candida Deniz Naranjo,Paolo Bosco,Robert Clarke,Carol Brayne,Daniela Galimberti,Michelangelo Mancuso,Fiona E. Matthews,Genetic,Environmental Risk in Alzheimer's Disease,Environmental Risk in Alzheimer's Disease,Cohorts for Heart,Cohorts for Heart,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Wolfgang Maier,Harald Hampel,Harald Hampel,Alberto Pilotto,María J. Bullido,María J. Bullido,Francesco Panza,Paolo Caffarra,Paolo Caffarra,Benedetta Nacmias,John R. Gilbert,Manuel Mayhaus,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M. Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alvarez,Fanggeng Zou,Otto Valladares,Steven G. Younkin,Eliecer Coto,Kara L. Hamilton-Nelson,Wei Gu,Cristina Razquin,Pau Pastor,Ignacio Mateo,Michael John Owen,Kelley Faber,Palmi V. Jonsson,Onofre Combarros,Michael Conlon O'Donovan,Laura B. Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H. Mosley,David A. Bennett,Tamara B. Harris,Laura Fratiglioni,Laura Fratiglioni,Clive Holmes,Renée F.A.G. de Bruijn,Peter Passmore,Thomas J. Montine,Karolien Bettens,Karolien Bettens,Jerome I. Rotter,Alexis Brice,Alexis Brice,Kevin Morgan,Tatiana Foroud,Walter A. Kukull,Didier Hannequin,John Powell,Mike A. Nalls,Karen Ritchie,Kathryn L. Lunetta,John S. K. Kauwe,Eric Boerwinkle,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R. Martin,Reinhold Schmidt,Dan Rujescu,Li-San Wang,Jean-François Dartigues,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M. Nöthen,Caroline Graff,Caroline Graff,Bruce M. Psaty,Bruce M. Psaty,Lesley Jones,Jonathan L. Haines,Peter Holmans,Mark Lathrop,Mark Lathrop,Margaret A. Pericak-Vance,Lenore J. Launer,Lindsay A. Farrer,Cornelia M. van Duijn,Christine Van Broeckhoven,Christine Van Broeckhoven,Valentina Moskvina,Sudha Seshadri,Julie Williams,Gerard D. Schellenberg,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel +215 more
TL;DR: In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Journal ArticleDOI
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
Valentina Escott-Price,Céline Bellenguez,Li-San Wang,Seung Hoan Choi,Denise Harold,Lesley Jones,Peter Holmans,Amy Gerrish,Alexey Vedernikov,Alexander Richards,Anita L. DeStefano,Jean-Charles Lambert,Carla A. Ibrahim-Verbaas,Adam C. Naj,Rebecca Sims,Gyungah Jun,Joshua C. Bis,Gary W. Beecham,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A. Thornton-Wells,Nicola Denning,Albert V. Smith,Vincent Chouraki,Charlene Thomas,M. Arfan Ikram,Diana Zelenika,Badri N. Vardarajan,Badri N. Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Helena Schmidt,Brian W. Kunkle,Melanie L. Dunstan,Maria Vronskaya,Andrew D. Johnson,Agustín Ruiz,Marie-Thérèse Bihoreau,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Olivier Hanon,Annette L. Fitzpatrick,Joseph D. Buxbaum,Dominique Campion,Paul K. Crane,Clinton T. Baldwin,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga,David Craig,Najaf Amin,Claudine Berr,Oscar L. Lopez,Philip L. De Jager,Philip L. De Jager,Vincent Deramecourt,Janet A. Johnston,Denis A. Evans,Simon Lovestone,Luc Letenneur,Isabel Hernández,David C. Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Alison Goate,Nathalie Fievet,Matthew J. Huentelman,Michael Gill,Kristelle Brown,M. Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B. Larson,Eric B. Larson,Amanda J. Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Jordi Clarimón,Alberto Lleó,Antony James Bayer,Debby W. Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petra Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez Garcia,Nick C. Fox,John Hardy,Maria Candida Deniz Naranjo,Paolo Bosco,Robert Clarke,Carol Brayne,Daniela Galimberti,Elio Scarpini,Ubaldo Bonuccelli,Michelangelo Mancuso,Gabriele Siciliano,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Harald Hampel,Alberto Pilotto,Ana Frank-García,Francesco Panza,Vincenzo Solfrizzi,Paolo Caffarra,Benedetta Nacmias,William Perry,Manuel Mayhaus,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M. Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alvarez,Fanggeng Zou,Otto Valladares,Steven G. Younkin,Eliecer Coto,Kara L. Hamilton-Nelson,Wei Gu,Cristina Razquin,Pau Pastor,Ignacio Mateo,Michael John Owen,Kelley Faber,Palmi V. Jonsson,Onofre Combarros,Michael Conlon O'Donovan,Laura B. Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H. Mosley,David A. Bennett,Tamara B. Harris,Laura Fratiglioni,Laura Fratiglioni,Clive Holmes,Renée F.A.G. de Bruijn,Peter Passmore,Thomas J. Montine,Karolien Bettens,Jerome I. Rotter,Alexis Brice,Kevin Morgan,Tatiana Foroud,Walter A. Kukull,Didier Hannequin,John Powell,Mike A. Nalls,Karen Ritchie,Kathryn L. Lunetta,John S. K. Kauwe,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R. Martin,Reinhold Schmidt,Dan Rujescu,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M. Nöthen,Caroline Graff,Bruce M. Psaty,Bruce M. Psaty,Jonathan L. Haines,Jonathan L. Haines,Mark Lathrop,Margaret A. Pericak-Vance,Lenore J. Launer,Christine Van Broeckhoven,Lindsay A. Farrer,Cornelia M. van Duijn,Alfredo Ramirez,Sudha Seshadri,Sudha Seshadri,Gerard D. Schellenberg,Philippe Amouyel,Julie Williams +194 more
TL;DR: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimers disease.
Journal ArticleDOI
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims,Sven J. van der Lee,Adam C. Naj,Céline Bellenguez,Céline Bellenguez,Nandini Badarinarayan,Johanna Jakobsdottir,Brian W. Kunkle,Anne Boland,Rachel Raybould,Joshua C. Bis,Eden R. Martin,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Stefanie Heilmann-Heimbach,Vincent Chouraki,Vincent Chouraki,Amanda B. Kuzma,Kristel Sleegers,Kristel Sleegers,Maria Vronskaya,Agustín Ruiz,Robert R. Graham,Robert Olaso,Per Hoffmann,Per Hoffmann,Megan L. Grove,Badri N. Vardarajan,Mikko Hiltunen,Markus M. Nöthen,Charles C. White,Kara L. Hamilton-Nelson,Jacques Epelbaum,Wolfgang Maier,Wolfgang Maier,Seung Hoan Choi,Gary W. Beecham,Cécile Dulary,Stefan Herms,Stefan Herms,Albert V. Smith,Cory C. Funk,Céline Derbois,Andreas J. Forstner,Shahzad Ahmad,Hong-Dong Li,Delphine Bacq,Denise Harold,Claudia L. Satizabal,Claudia L. Satizabal,Otto Valladares,Alessio Squassina,Rhodri Thomas,Jennifer A. Brody,Liming Qu,Pascual Sánchez-Juan,Taniesha Morgan,Frank J. Wolters,Yi Zhao,Florentino Sanchez Garcia,Nicola Denning,Myriam Fornage,John Malamon,Maria Candida Deniz Naranjo,Elisa Majounie,Thomas H. Mosley,Beth A. Dombroski,David Wallon,Michelle K. Lupton,Michelle K. Lupton,Josée Dupuis,Patrice L. Whitehead,Laura Fratiglioni,Laura Fratiglioni,Christopher Medway,Xueqiu Jian,Shubhabrata Mukherjee,Lina Keller,Kristelle Brown,Honghuang Lin,Laura B. Cantwell,Francesco Panza,Bernadette McGuinness,Sonia Moreno-Grau,Jeremy D. Burgess,Vincenzo Solfrizzi,Petra Proitsi,Hieab H.H. Adams,Mariet Allen,Davide Seripa,Pau Pastor,L. Adrienne Cupples,L. Adrienne Cupples,Nathan D. Price,Didier Hannequin,Ana Frank-García,Ana Frank-García,Daniel Levy,Daniel Levy,Paramita Chakrabarty,Paolo Caffarra,Paolo Caffarra,Ina Giegling,Alexa S. Beiser,Alexa S. Beiser,Vilmantas Giedraitis,Harald Hampel,Harald Hampel,Melissa E. Garcia,Xue Wang,Lars Lannfelt,Patrizia Mecocci,Gudny Eiriksdottir,Paul K. Crane,Florence Pasquier,Florence Pasquier,Virginia Boccardi,Isabel Henández,Robert Barber,Martin Scherer,Lluís Tárraga,Perrie M. Adams,Markus Leber,Yuning Chen,Marilyn S. Albert,Steffi G. Riedel-Heller,Valur Emilsson,Duane Beekly,Anne Braae,Reinhold Schmidt,Deborah Blacker,Carlo Masullo,Helena Schmidt,Rachelle S. Doody,Gianfranco Spalletta,W. T. Longstreth,Thomas Fairchild,Paola Bossù,Oscar L. Lopez,Matthew P. Frosch,Eleonora Sacchinelli,Bernardino Ghetti,Qiong Yang,Ryan M. Huebinger,Frank Jessen,Frank Jessen,Frank Jessen,Shuo Li,M. Ilyas Kamboh,John C. Morris,Oscar Sotolongo-Grau,Mindy J. Katz,Chris Corcoran,Melanie L. Dunstan,Amy Braddel,Charlene Thomas,Alun Meggy,Rachel Marshall,Amy Gerrish,Jade Chapman,Miquel Aguilar,Sarah Taylor,Matt Hill,Monica Diez Fairen,Angela Hodges,Bruno Vellas,Hilkka Soininen,Iwona Kłoszewska,Makrina Daniilidou,James Uphill,Yogen Patel,Joseph T. Hughes,Jenny Lord,James Turton,Annette M. Hartmann,Roberta Cecchetti,Chiara Fenoglio,Maria Serpente,Marina Arcaro,Carlo Caltagirone,Maria Donata Orfei,Antonio Ciaramella,Sabrina Pichler,Manuel Mayhaus,Wei Gu,Alberto Lleó,Juan Fortea,Rafael Blesa,Imelda Barber,Keeley J. Brookes,Chiara Cupidi,Raffaele Maletta,David Carrell,Sandro Sorbi,Susanne Moebus,Maria Urbano,Alberto Pilotto,Johannes Kornhuber,Paolo Bosco,Stephen Todd,David Craig,Janet A. Johnston,Michael Gill,Brian A. Lawlor,Aoibhinn Lynch,Nick C. Fox,John Hardy,Roger L. Albin,Liana G. Apostolova,Liana G. Apostolova,Liana G. Apostolova,Steven E. Arnold,Sanjay Asthana,Craig S. Atwood,Clinton T. Baldwin,Lisa L. Barnes,Sandra Barral,Thomas G. Beach,James T. Becker,Eileen H. Bigio,Thomas D. Bird,Bradley F. Boeve,James Bowen,Adam L. Boxer,James R. Burke,Jeffrey M. Burns,Joseph D. Buxbaum,Nigel J. Cairns,Chuanhai Cao,Christopher S. Carlson,Cynthia M. Carlsson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,Carolina Ceballos Diaz,Helena C. Chui,David G. Clark,David G. Clark,David H. Cribbs,Elizabeth Crocco,Charles DeCarli,Malcolm B. Dick,Ranjan Duara,Denis A. Evans,Kelley Faber,Kenneth B. Fallon,David W. Fardo,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Douglas Galasko,Marla Gearing,Daniel H. Geschwind,John R. Gilbert,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Lawrence S. Honig,Matthew J. Huentelman,Christine M. Hulette,Bradley T. Hyman,Gail P. Jarvik,Erin L. Abner,Lee-Way Jin,Gyungah Jun,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Neil W. Kowall,Joel H. Kramer,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Andrew P. Lieberman,Kathryn L. Lunetta,Constantine G. Lyketsos,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Jill R. Murrell,Amanda J. Myers,Sid E. O'Bryant,John M Olichney,Vernon S. Pankratz,Joseph E. Parisi,Henry L. Paulson,William Perry,Elaine R. Peskind,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Ekaterina Rogaeva,Howard J. Rosen,Roger N. Rosenberg,Mark A. Sager,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Russell H. Swerdlow,Rudolph E. Tanzi,Tricia A. Thornton-Wells,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Linda J. Van Eldik,Harry V. Vinters,Jean Paul G. Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Kirk C. Wilhelmsen,Jennifer Williamson,Thomas S. Wingo,Randall L. Woltjer,Clinton B. Wright,Chang En Yu,Lei Yu,Fabienne Garzia,Feroze Golamaully,Gislain Septier,Sebastien Engelborghs,Rik Vandenberghe,Peter Paul De Deyn,Carmen Muñoz Fernadez,Yoland Aladro Benito,Håkan Thonberg,Charlotte Forsell,Lena Lilius,Anne Kinhult-Ståhlbom,Lena Kilander,RoseMarie Brundin,Letizia Concari,Letizia Concari,Seppo Helisalmi,Anne M. Koivisto,Annakaisa Haapasalo,Vincent Dermecourt,Nathalie Fievet,Olivier Hanon,Carole Dufouil,Carole Dufouil,Alexis Brice,Alexis Brice,Karen Ritchie,Bruno Dubois,Bruno Dubois,Jayanadra J. Himali,C. Dirk Keene,JoAnn T. Tschanz,Annette L. Fitzpatrick,Walter A. Kukull,Maria C. Norton,Thor Aspelund,Eric B. Larson,Eric B. Larson,Ronald G. Munger,Jerome I. Rotter,Richard B. Lipton,María J. Bullido,María J. Bullido,Albert Hofman,Thomas J. Montine,Eliecer Coto,Eric Boerwinkle,Eric Boerwinkle,Ronald C. Petersen,Victoria Alvarez,Fernando Rivadeneira,Eric M. Reiman,Maura Gallo,Christopher J. O'Donnell,Joan S. Reisch,Amalia C. Bruni,Donald R. Royall,Martin Dichgans,Martin Dichgans,Mary Sano,Daniela Galimberti,Peter St George-Hyslop,Peter St George-Hyslop,Elio Scarpini,Debby W. Tsuang,Michelangelo Mancuso,Ubaldo Bonuccelli,Ashley R. Winslow,Antonio Daniele,Chuang Kuo Wu,Oliver Peters,Benedetta Nacmias,Matthias Riemenschneider,Reinhard Heun,Carol Brayne,David C. Rubinsztein,Jose Bras,Jose Bras,Rita Guerreiro,Rita Guerreiro,Ammar Al-Chalabi,Christopher Shaw,John Collinge,David G. Mann,David G. Mann,Jordi Clarimón,Rebecca Sussams,Simon Lovestone,Michael Conlon O'Donovan,Michael John Owen,Timothy W. Behrens,Simon Mead,André G. Uitterlinden,André G. Uitterlinden,Carlos Cruchaga,Martin Ingelsson,David A. Bennett,John Powell,Todd E. Golde,Caroline Graff,Philip L. De Jager,Kevin Morgan,Nilufer Ertekin-Taner,Onofre Combarros,Bruce M. Psaty,Peter Passmore,Steven G. Younkin,Claudine Berr,Vilmundur Gudnason,Dan Rujescu,Dennis W. Dickson,Jean-François Dartigues,Anita L. DeStefano,Anita L. DeStefano,Sara Ortega-Cubero,Hakon Hakonarson,Dominique Campion,Mercè Boada,John K Kauwe,Lindsay A. Farrer,Christine Van Broeckhoven,Christine Van Broeckhoven,M. Arfan Ikram,Lesley Jones,Jonathan L. Haines,Christophe Tzourio,Lenore J. Launer,Lenore J. Launer,Valentina Escott-Price,Richard Mayeux,Jean-François Deleuze,Najaf Amin,Alison Goate,Margaret A. Pericak-Vance,Peter Holmans,Cornelia M. van Duijn,Alfredo Ramirez,Alfredo Ramirez,Li-San Wang,Jean-Charles Lambert,Jean-Charles Lambert,Sudha Seshadri,Sudha Seshadri,Julie Williams,Gerard D. Schellenberg +487 more
TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.
Journal ArticleDOI
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez,Fahri Küçükali,Iris E. Jansen,Luca Kleineidam,Sonia Moreno-Grau,Najaf Amin,Adam C. Naj,R. Campos-Martín,Benjamin Grenier-Boley,Víctor Andrade,Peter Holmans,Anne Boland,Vincent Damotte,S. J. van der Lee,Marcos R. Costa,Teemu Kuulasmaa,Qiong Yang,Itziar de Rojas,Joshua C. Bis,Amber Yaqub,Ivana Prokic,Julien Chapuis,Shahzad Ahmad,Vilmantas Giedraitis,Dag Aarsland,Carla Abdelnour,Emilio Alarcón-Martín,Daniel Alcolea,Montserrat Alegret,Ignacio Alvarez,Victoria Alvarez,Nicola J. Armstrong,Anthoula Tsolaki,Carmen Antúnez,Ildebrando Appollonio,Marina Arcaro,Silvana Archetti,Alfonso Arias Pastor,Beatrice Arosio,Lavinia Athanasiu,Henri Bailly,Nerisa Banaj,Miquel Baquero,Sandra Barral,Alexa S. Beiser,Ana Pastor,Jennifer E. Below,Penny Benchek,Luisa Benussi,Claudine Berr,Céline Besse,Valentina Bessi,Giuliano Binetti,Alessandra Bizarro,Rafael Blesa,Mercè Boada,Eric Boerwinkle,S. Borroni,Silvia Boschi,Paola Bossù,Geir Bråthen,Jan Bressler,Catherine Bresner,Henry Brodaty,Keeley J. Brookes,Luis I. Brusco,Dolores Buiza-Rueda,Katharina Bürger,Vanessa Burholt,William S. Bush,Miguel Calero,Laura B. Cantwell,Geneviève Chêne,Jaeyoon Chung,Michael L. Cuccaro,Angel Carracedo,Roberta Cecchetti,Laura Cervera-Carles,Camille Charbonnier,Hung-Hsin Chen,Caterina Chillotti,Simona Ciccone,Jurgen A.H.R. Claassen,Christopher M. Clark,Elisa Conti,Anaïs Corma-Gómez,Emanuele Maria Costantini,Carlo Custodero,D. Daian,Maria Carolina Dalmasso,Antonio Daniele,Efthimios Dardiotis,Jean-François Dartigues,Peter Paul De Deyn,Katia de Paiva Lopes,Lot de Witte,Stéphanie Debette,Jürgen Deckert,Teodoro Del Ser,Nicola Denning,Anita L. DeStefano,Martin Dichgans,Janine Diehl-Schmid,Monica Diez-Fairen,Paolo Rosso,Srdjan Djurovic,Emmanuelle Duron,Emrah Düzel,Carole Dufouil,Gudny Eiriksdottir,Sebastiaan Engelborghs,Valentina Escott-Price,Ana Espinosa,Michael Ewers,Kelley Faber,Tagliavini Fabrizio,Sune F. Nielsen,David W. Fardo,Lucia Farotti,Chiara Fenoglio,Marta Fernández-Fuertes,Raffaele Ferrari,Catarina Beatriz Silva Ferreira,Evelyn Ferri,Bertrand Fin,Peter Fischer,Tormod Fladby,Klaus Fliessbach,Bernard Fongang,Myriam Fornage,Juan Fortea,Tatiana Foroud,Silvia Fostinelli,Nick C. Fox,Emilio Franco-Macías,María J. Bullido,Ana Frank-García,Lutz Froelich,Brian Fulton-Howard,Daniela Galimberti,José María García-Alberca,Pablo Garcia-Gonzalez,Sebastián García-Madrona,Guillermo García-Ribas,Roberta Ghidoni,Ina Giegling,Giaccone Giorgio,Alison Goate,Oliver Goldhardt,Duber Gomez-Fonseca,Antonio González-Pérez,Caroline Graff,Giulia Grande,Emma Green,Timo Grimmer,Edna Grünblatt,Michelle Grunin,Vilmundur Gudnason,Tamar Guetta-Baranes,Annakaisa Haapasalo,Georgios M. Hadjigeorgiou,Jonathan L. Haines,Kara L. Hamilton-Nelson,Harald Hampel,Olivier Hanon,John Hardy,T. Hartmann,Lucrezia Hausner,Janet C Harwood,Stefanie Heilmann-Heimbach,Seppo Helisalmi,Michael T. Heneka,Isabel Hernández,Martin J. Herrmann,Per Hoffmann,Clive Holmes,Henne Holstege,Raquel Huerto Vilas,Marc Hulsman,Jack Humphrey,Geert Jan Biessels,Xueqiu Jian,Charlotte Johansson,Gyungah Jun,Y. Kastumata,John S. K. Kauwe,Patrick G. Kehoe,Lena Kilander,Anne Kinhult Ståhlbom,Miia Kivipelto,Anne M. Koivisto,Johannes Kornhuber,Mary H. Kosmidis,Walter A. Kukull,Pavel P. Kuksa,Brian W. Kunkle,Amanda B. Kuzma,Carmen Lage,Erika J. Laukka,Lenore J. Launer,Alessandra Lauria,Chien‐Yueh Lee,Jenni Lehtisalo,Ondrej Lerch,Alberto Lleó,W. T. Longstreth,Oscar L. Lopez,Adolfo López de Munain,Seth Love,Malin Löwemark,L. Luckcuck,Kathryn L. Lunetta,Yiyi Ma,Juan Macías,Catherine A. MacLeod,Wolfgang Mader,Francesca Mangialasche,Marco Spallazzi,Marta Marquié,Rachel Marshall,Eden R. Martin,Angel Martin Montes,Carmen Martinez Rodriguez,Carlo Masullo,Richard Mayeux,Simon Head,Patrizia Mecocci,Miguel Medina,Alun Meggy,Shima Mehrabian,Silvia Mendoza,Manuel Menéndez-González,Pablo Mir,Susanne Moebus,Merel O. Mol,Laura Molina-Porcel,Laura Montrreal,Laura Morelli,Fermin Moreno,Kevin Morgan,Thomas H. Mosley,Markus M. Nöthen,Carolina Muchnik,Shubhabrata Mukherjee,Benedetta Nacmias,Tiia Ngandu,Gaël Nicolas,Børge G. Nordestgaard,Robert Olaso,Adelina Orellana,Michela Orsini,G. Ortega,Alessandro Padovani,Caffarra Paolo,Goran Papenberg,Lucilla Parnetti,Florence Pasquier,Pau Pastor,Gina M. Peloso,Alba Pérez-Cordón,Jordi Pérez-Tur,Pierre Pericard,Oliver Peters,Yolande A.L. Pijnenburg,Juan A. Pineda,Gerard Piñol-Ripoll,Claudia Pisanu,Thomas Polak,Julius Popp,Danielle Posthuma,Josef Priller,Raquel Delgado Puerta,Olivier Quenez,Inés Quintela,Jesper Qvist Thomassen,Alberto Rábano,Innocenzo Rainero,Farid Rajabli,Inez H.G.B. Ramakers,Luis Miguel Real,Marcel J. T. Reinders,Christiane Reitz,Dolly Reyes-Dumeyer,Perry G. Ridge,Steffi G. Riedel-Heller,Peter Riederer,Natalia Roberto,Eloy Rodríguez-Rodríguez,Arvid Rongve,I. Allende,Maitée Rosende-Roca,Jose Luis Royo,Elisa Rubino,Dan Rujescu,María Eugenia Sáez,Paraskevi Sakka,Ingvild Saltvedt,Angela Sanabria,M B Sánchez-Arjona,Florentino Sanchez-Garcia,Pascual Sanchez Juan,Raquel Sánchez-Valle,Sigrid Botne Sando,Chloé Sarnowski,Claudia L. Satizabal,Michela Scamosci,Nikolaos Scarmeas,Elio Scarpini,Philip Scheltens,Norbert Scherbaum,Martin Scherer,Matthias Schmid,Anja Schneider,Jonathan M. Schott,Geir Selbæk,Davide Seripa,Manuel Serrano,Jin Sha,Alexey A. Shadrin,Olivia Anna Skrobot,Susan Slifer,G. Snijders,Hilkka Soininen,Vincenzo Solfrizzi,Alina Solomon,Yeunjoo E. Song,Sandro Sorbi,Oscar Sotolongo-Grau,Gianfranco Spalletta,Annika Spottke,Alessio Squassina,Eystein Stordal,Juan Pablo Tartan,Lluís Tárraga,Niccolò Tesi,Anbupalam Thalamuthu,Tegos Thomas,Giuseppe Tosto,Latchezar Traykov,Lucio Tremolizzo,Anne Tybjærg-Hansen,André G. Uitterlinden,Abbe Ullgren,Ingun Ulstein,Sergi Valero,Otto Valladares,Christine Van Broeckhoven,Jeffery M. Vance,Badri N. Vardarajan,Aad Van Der Lugt,Jasper Van Dongen,Jeroen van Rooij,John C. van Swieten,Rik Vandenberghe,Frans R.J. Verhey,Jean-Sébastien Vidal,Jonathan Vogelgsang,Martin Vyhnalek,Michael Wagner,David Wallon,Li-San Wang,Ruiqi Wang,Leonie Weinhold,Jens Wiltfang,Gill Windle,Bob Woods,Mary Yannakoulia,Habil Zare,Yi Zhao,Xiaoling Zhang,Congcong Zhu,Miren Zulaica,Lindsay A. Farrer,Bruce M. Psaty,Mohsen Ghanbari,Towfique Raj,Perminder S. Sachdev,Karen A. Mather,Frank Jessen,M. Arfan Ikram,Alexandre de Mendonça,Jakub Hort,Magda Tsolaki,Margaret A. Pericak-Vance,Philippe Amouyel,Julie Williams,Ruth Frikke-Schmidt,Jordi Clarimón,Jean-François Deleuze,Giacomina Rossi,Sudha Seshadri,Ole A. Andreassen,Martin Ingelsson,Mikko Hiltunen,Kristel Sleegers,Gerard D. Schellenberg,Cornelia M. van Duijn,Rebecca Sims,Wiesje M. van der Flier,Agustín Ruiz,Alfredo Ramirez,Jean-Charles Lambert +401 more
TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.
Journal ArticleDOI
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
David C. Whitcomb,Jessica LaRusch,Alyssa M. Krasinskas,Lambertus Klei,Jill P. Smith,Randall E. Brand,John P. Neoptolemos,Markus M. Lerch,Matt Tector,Bimaljit S. Sandhu,Nalini M. Guda,Lidiya Orlichenko,Samer Alkaade,Stephen T. Amann,Michelle A. Anderson,John Baillie,Peter A. Banks,Darwin L. Conwell,Gregory A. Cote,Peter B. Cotton,James A. DiSario,Lindsay A. Farrer,Chris E. Forsmark,Marianne Johnstone,Timothy B. Gardner,Andres Gelrud,William Greenhalf,Jonathan L. Haines,Douglas J. Hartman,Robert A. Hawes,Christopher Lawrence,Michele D. Lewis,Julia Mayerle,Richard Mayeux,Nadine M. Melhem,Mary E. Money,Thiruvengadam Muniraj,Georgios I. Papachristou,Margaret A. Pericak-Vance,Joseph Romagnuolo,Gerard D. Schellenberg,Stuart Sherman,Peter Simon,Vijay P. Singh,Adam Slivka,Donna B. Stolz,Robert Sutton,Frank Ulrich Weiss,C. Mel Wilcox,Narcis O. Zarnescu,Stephen R. Wisniewski,Michael R. O'Connell,Michelle L. Kienholz,Kathryn Roeder,M. Michael Barmada,Dhiraj Yadav,Bernie Devlin,Marilyn S. Albert,Roger L. Albin,Roger L. Albin,Liana G. Apostolova,Steven E. Arnold,Clinton T. Baldwin,Robert Barber,Lisa L. Barnes,Thomas G. Beach,Gary W. Beecham,Duane Beekly,David A. Bennett,Eileen H. Bigio,Thomas D. Bird,Deborah Blacker,Adam L. Boxer,James R. Burke,Joseph D. Buxbaum,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Regina M. Carney,Steven L. Carroll,Helena C. Chui,David G. Clark,David H. Cribbs,Elizabeth Crocco,Carlos Cruchaga,Charles DeCarli,F. Yesim Demirci,Malcolm B. Dick,Dennis W. Dickson,Ranjan Duara,Nilufer Ertekin-Taner,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Jonathan D. Glass,Alison Goate,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Hakon Hakonarson,Kara L. Hamilton-Nelson,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Gyungah Jun,M. Ilyas Kamboh,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Patricia L. Kramer,Walter A. Kukul,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Chiao-Feng Lin,Andrew P. Lieberman,Oscar L. Lopez,Kathryn L. Lunetta,Constantine G. Lyketsos,Wendy J. Mack,Daniel C. Marson,Eden R. Martin,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Thomas J. Montine,John C. Morris,Jill R. Murrel,Adam C. Naj,Adam C. Naj,John M Olichney,Joseph E. Parisi,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Eric M. Reiman,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Howard J. Rosen,Roger N. Rosenberg,Mary Sano,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Juan C. Troncoso,Debby W. Tsuang,Otto Valladares,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsatte,Li-San Wang,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Clinton B. Wright,Steven G. Younkin,Chang En Yu,Lei Yu +201 more
TL;DR: Two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 are reported and could partially explain the high frequency of alcohol-related pancreatitis in men.