Hervé Blanc

TL;DR: ExoN is identified as the first viral protein distinct from the RdRp that determines the sensitivity of RNA viruses to mutagens, and shows the importance of ExoN as a target for inhibition, and suggests that small-molecule inhibitors of ExON activity could be potential pan-CoV therapeutics in combination with RBV or RNA mutagen.

TL;DR: A unique arbovirus fidelity variant with a single C483Y amino acid change in the nsP4 RdRp that increases replication fidelity and generates populations with reduced genetic diversity is described.

TL;DR: It is shown that mosquito cells derived from the two main vectors for arboviruses can initiate de novo piRNA production and recapitulate the ping-pong dependent piRNA pathway upon viral infection.

TL;DR: This work shows that two species of Aedes mosquitoes infected with two arboviruses from distinct families generate a viral-derived DNA (vDNA) that is essential for mosquito survival and viral tolerance and highlights an essential role of vDNA in viral tolerance that allowsMosquitoes survival and thus may be important forArbovirus dissemination and transmission.

TL;DR: Results indicate that nsp12-RdRp likely functions in fidelity regulation and that, despite low sequence conservation, some determinants of RdRp nucleotide selectivity are conserved across RNA viruses.