M
Maria-Carla Saleh
Researcher at Pasteur Institute
Publications - 61
Citations - 3821
Maria-Carla Saleh is an academic researcher from Pasteur Institute. The author has contributed to research in topics: RNA interference & Viral replication. The author has an hindex of 27, co-authored 55 publications receiving 3275 citations. Previous affiliations of Maria-Carla Saleh include National University of Cordoba & Centre national de la recherche scientifique.
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Journal ArticleDOI
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster.
Ronald P. van Rij,Maria-Carla Saleh,Bassam Berry,Catherine K. Foo,Andrew R. Houk,Christophe Antoniewski,Raul Andino +6 more
TL;DR: The central catalytic component of the RNA-induced silencing complex (RISC), the nuclease Argonaute 2 (Ago-2), is essential for antiviral defense in adult Drosophila melanogaster.
Journal ArticleDOI
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
Maria-Carla Saleh,Ronald P. van Rij,Armin Hekele,Amethyst Gillis,Edan Foley,Edan Foley,Patrick H. O'Farrell,Raul Andino +7 more
TL;DR: The pathway for dsRNA uptake in Drosophila melanogaster S2 cells is identified and appears to be evolutionarily conserved, as knockdown of orthologues in Caenorhabditis elegans inactivated the RNA interference response in worms.
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Antiviral immunity in Drosophila requires systemic RNA interference spread
Maria-Carla Saleh,Maria-Carla Saleh,Michel Tassetto,Ronald P. van Rij,Ronald P. van Rij,Bertsy Goic,Valérie Gausson,Bassam Berry,Bassam Berry,Caroline Jacquier,Caroline Jacquier,Christophe Antoniewski,Christophe Antoniewski,Raul Andino +13 more
TL;DR: It is shown that a recently defined double-stranded RNA (dsRNA) uptake pathway is essential for effective antiviral RNAi immunity in adult flies, and that spread of dsRNA to uninfected sites is essential.
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RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila
Bertsy Goic,Nicolas Vodovar,Juan A Mondotte,Clément Monot,Lionel Frangeul,Hervé Blanc,Valérie Gausson,Jorge Vera-Otarola,Gaël Cristofari,Maria-Carla Saleh +9 more
TL;DR: This work finds that the persistence of RNA viruses in Drosophila melanogaster was achieved through the combined action of cellular reverse-transcriptase activity and the RNA-mediated interference (RNAi) pathway.
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Arbovirus-derived piRNAs exhibit a ping-pong signature in mosquito cells.
Nicolas Vodovar,Alfred W. Bronkhorst,Koen W. R. van Cleef,Pascal Miesen,Hervé Blanc,Ronald P. van Rij,Maria-Carla Saleh +6 more
TL;DR: It is shown that mosquito cells derived from the two main vectors for arboviruses can initiate de novo piRNA production and recapitulate the ping-pong dependent piRNA pathway upon viral infection.