Hideaki Sowa

TL;DR: It was shown that plasma LDL-C and HDL-C levels were inversely and positively correlated with both R- and L-BMD values, respectively, while low plasma TG levels were associated with the presence of vertebral fractures in postmenopausal women.

TL;DR: Ghrelin was identified in the stomach as an endogenous ligand specific for the growth hormone secretagogue receptor (GHS-R) and its findings raise the possibility that ghrelin modulates insulin activities in humans.

TL;DR: Treatment of postmenopausal women with an antibody targeted against sclerostin resulted in substantial increases in spine and hip BMD, and further study of blosozumab as a potential anabolic therapy for osteoporosis is supported.

TL;DR: Menin interacts physically and functionally with Runx2 in uncommitted mesenchymal stem cells, but not in well differentiated osteoblasts, where the interaction of menin and the transforming growth factor-β/ Smad3 pathway negatively regulates the BMP-2/Smad1/5- and Runx-2-induced transcriptional activities leading to inhibition of late-stage differentiation.

TL;DR: VBMD evaluation revealed that an excess of endogenous PTH was catabolic for both cortical and trabecular bones, and that bone mass was preserved under a condition of deficient endogenous Pth, which might partly compensate for a decrease in bone strength induced by low BMD.