H
Hideto Ohno
Researcher at Mitsubishi Chemical Corporation
Publications - 8
Citations - 981
Hideto Ohno is an academic researcher from Mitsubishi Chemical Corporation. The author has contributed to research in topics: Tau protein & Peptide sequence. The author has an hindex of 7, co-authored 8 publications receiving 938 citations.
Papers
More filters
Journal ArticleDOI
Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.
Harald Hampel,Katharina Buerger,Raymond Zinkowski,Stefan J. Teipel,Alexander Goernitz,Niels Andreasen,Magnus Sjoegren,John DeBernardis,Daniel J. Kerkman,Koichi Ishiguro,Hideto Ohno,Eugeen Vanmechelen,Hugo Vanderstichele,Cheryl McCulloch,Hans-Jürgen Möller,Peter Davies,Kaj Blennow +16 more
TL;DR: The p-tau proteins in CSF come closest to fulfilling the criteria of a biological marker of AD, and Combinations of the 3 markers did not add discriminative power compared with the application as single markers.
Journal ArticleDOI
Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease
Nobuo Itoh,Hiroyuki Arai,Katsuya Urakami,Koichi Ishiguro,Hideto Ohno,Harald Hampel,Katharina Buerger,Jens Wiltfang,Markus Otto,Hans A. Kretzschmar,Hans Juergen Moeller,Masaki Imagawa,Hideki Kohno,Kenji Nakashima,Shigeki Kuzuhara,Hidetada Sasaki,Kazutomo Imahori +16 more
TL;DR: It is suggested that CSF/phospho‐tau199 may be a novel and logical biomarker in supporting antemortem diagnosis of AD.
Journal ArticleDOI
Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease.
Koichi Ishiguro,Hideto Ohno,Hiroyuki Arai,Haruyasu Yamaguchi,Katsuya Urakami,Jung-Mi Park,Kazuki Sato,Hideki Kohno,Kazutomo Imahori +8 more
TL;DR: Elevated phosphorylated CSF-tau levels were significantly higher in AD patients than those in non-AD controls, indicating that elevated phosphorylation in CSF is a more specific diagnostic marker for AD.
Journal ArticleDOI
CSF Phosphorylated Tau Protein and Mild Cognitive Impairment: A Prospective Study
Hiroyuki Arai,Koichi Ishiguro,Hideto Ohno,Michiko Moriyama,Nobuo Itoh,Nobuyuki Okamura,Toshifumi Matsui,Yu Ichi Morikawa,Etsuo Horikawa,Hideki Kohno,Hidetada Sasaki,Kazutomo Imahori +11 more
TL;DR: The results suggest that the pathogenic steps of AD may be at the stage that finally leads to an accumulation of abnormally phosphorylated tau and neuron death, at least in some brain areas, when MCI patients present with the earliest detectable clinical symptoms of dementia.
Patent
Antibody specific to central nervous system tau protein
TL;DR: In this article, the authors presented an antibody which specifically recognizes a CNS tau protein but not a peripheral tau proteins, and further provided a method of detecting Alzheimer's disease and a reagent kit using the antibody.