Journal ArticleDOI
Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease.
Koichi Ishiguro,Hideto Ohno,Hiroyuki Arai,Haruyasu Yamaguchi,Katsuya Urakami,Jung-Mi Park,Kazuki Sato,Hideki Kohno,Kazutomo Imahori +8 more
TLDR
Elevated phosphorylated CSF-tau levels were significantly higher in AD patients than those in non-AD controls, indicating that elevated phosphorylation in CSF is a more specific diagnostic marker for AD.About:
This article is published in Neuroscience Letters.The article was published on 1999-07-30. It has received 179 citations till now. The article focuses on the topics: Tau protein.read more
Citations
More filters
Journal ArticleDOI
Mild cognitive impairment
Serge Gauthier,Barry Reisberg,Michael Zaudig,Ronald C. Petersen,Karen Ritchie,Karl Broich,Sylvie Belleville,Henry Brodaty,David A. Bennett,Howard Chertkow,Jeffrey L. Cummings,Mony J. de Leon,Howard Feldman,Mary Ganguli,Harald Hampel,Philip Scheltens,Mary C. Tierney,Peter J. Whitehouse,Bengt Winblad +18 more
TL;DR: Mild cognitive impairment can be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension.
Journal ArticleDOI
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Bruno Dubois,Howard Feldman,Claudia Jacova,Steven T. DeKosky,Pascale Barberger-Gateau,Jeffrey L. Cummings,André Delacourte,Douglas Galasko,Serge Gauthier,Gregory A. Jicha,Kenichi Meguro,John T. O'Brien,Florence Pasquier,Philippe Robert,Martin N. Rossor,Steven Salloway,Yaakov Stern,Pieter Jelle Visser,Philip Scheltens +18 more
TL;DR: The NINCDS-ADRDA and DSM-IV-TR criteria for Alzheimer's disease (AD) are the prevailing diagnostic standards in research; however, they have now fallen behind the unprecedented growth of scientific knowledge as discussed by the authors.
Journal ArticleDOI
CSF markers for incipient Alzheimer's disease
Kaj Blennow,Harald Hampel +1 more
TL;DR: The CSF biomarkers total tau protein, phosphorylated tauprotein, and the 42 amino-acid residue form of amyloid-beta may, if put in the right clinical context, prove to have high enough diagnostic accuracy to meet the challenge of identifying incipient AD in patients with MCI.
Journal ArticleDOI
Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease.
Trey Sunderland,Gary Linker,Nadeem Mirza,Karen Putnam,David L. Friedman,Lida H. Kimmel,Judy Bergeson,Guy J. Manetti,Matthew Zimmermann,Brian Tang,John J. Bartko,Robert M. Cohen +11 more
TL;DR: The findings suggest that the 2 measures, CSF beta-amyloid and tau, are biological markers of AD pathophysiology and may have a potential clinical utility as biomarkers of disease.
Journal ArticleDOI
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Masato Hasegawa,Tetsuaki Arai,Takashi Nonaka,Fuyuki Kametani,Mari Yoshida,Yoshio Hashizume,Thomas G. Beach,Emanuele Buratti,Francisco E. Baralle,Mitsuya Morita,Imaharu Nakano,Tatsuro Oda,Kuniaki Tsuchiya,Haruhiko Akiyama +13 more
TL;DR: The aim of this study was to identify the phosphorylation sites and responsible kinases, and to clarify the pathological significance ofosphorylation of TDP‐43.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
TL;DR: Antisera raised against synthetic peptides corresponding to these different human tau isoforms demonstrate that multiple tau protein isoforms are incorporated into the neurofibrillary tangles of Alzheimer's disease.
Journal ArticleDOI
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau
TL;DR: The major subunits of a class of PHFs are A68 proteins and the excessive or inappropriate phosphorylation of normal tau may change its apparent Mr, thus transforming tau into A68.
Journal ArticleDOI
Detection of Proteins in Normal and Alzheimer's Disease Cerebrospinal Fluid with a Sensitive Sandwich Enzyme‐Linked Immunosorbent Assay
Marc Vandermeeren,Marc Vandermeeren,Marc Mercken,Marc Mercken,Eugeen Vanmechelen,Jan Six,Jan Six,Andre Van De Voorde,Jean-Jacques Martin,Patrick Cras +9 more
TL;DR: CSF levels are significantly increased in Alzheimer's disease and a large group of patients with a diversity of neurological diseases showed overlap with CSF levels in Alzheimer’s disease.