Hideto Yonekura

TL;DR: Results suggest that cADP-ribose is a mediator of calcium release from islet microsomes and may be generated in islets by glucose stimulation, serving as a second messenger for calcium mobilization in the endoplasmic reticulum.

TL;DR: A role for CD38 is indicated in the synthesis and hydrolysis of cADPR in the process of insulin secretion in pancreatic beta-cells, and it is found that ATP (2-10 mM), generated in the glucose metabolism in beta- cells, inhibited the cAD PR-hydrolyzing activity, resulting in the increased formation of c ADPR.

TL;DR: Results indicate that Reg protein is a growth factor for pancreatic beta cells and suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus.

TL;DR: The human reg gene is isolated, determined its complete nucleotide sequence, and examined its expression in human tissues, indicating that the reg protein, pancreatic stone protein, and pancreatic thread protein are simply different names for a single protein deriving from the reg gene.

TL;DR: FK506, an immunosuppressant that prolongs allograft survival, as well as cADPR were found to induce the release of Ca2+ from islet microsomes, which strongly suggest that c ADPR may be the ligand for FKBP12.6 in islet RyR and that the binding of cAD PR to FK BP 12.6 frees the RyR from FKBA 12.