H
Hiep D. Le
Researcher at Salk Institute for Biological Studies
Publications - 25
Citations - 2894
Hiep D. Le is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Biology & Internal medicine. The author has an hindex of 12, co-authored 18 publications receiving 2184 citations. Previous affiliations of Hiep D. Le include Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Christopher Vollmers,Shubhroz Gill,Luciano DiTacchio,Sandhya R. Pulivarthy,Hiep D. Le,Satchidananda Panda +5 more
TL;DR: It is shown that both temporal pattern of food intake and the circadian clock drive rhythmic transcription, thereby highlighting temporal regulation of hepatic transcription as an emergent property of the circadian system.
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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
Ludovic S. Mure,Hiep D. Le,Giorgia Benegiamo,Max W. Chang,Max W. Chang,Luis C. Rios,Ngalla Jillani,Maina Ngotho,Thomas Kariuki,Ouria Dkhissi-Benyahya,Howard M. Cooper,Satchidananda Panda +11 more
TL;DR: The daily expression rhythms in >80% of protein-coding genes, encoding diverse biochemical and cellular functions, constitutes by far the largest regulatory mechanism that integrates diverse biochemical functions within and across cell types.
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Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
TL;DR: The results suggest that the circadian clock maintains metabolic homeostasis by sustaining daily rhythms in feeding and fasting and by maintaining balance between nutrient and cellular stress responses.
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Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses.
Megumi Hatori,Hiep D. Le,Christopher Vollmers,Sheena Racheal Keding,Nobushige Tanaka,Christian Schmedt,Timothy Jegla,Satchidananda Panda +7 more
TL;DR: The results point to the mRGCs as the site of functional integration of the rod/cone and melanopsin phototransduction pathways and as the primary anatomical site for the divergence of image-forming and non-image forming photoresponses in mammals.
Journal ArticleDOI
Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock
Luciano DiTacchio,Hiep D. Le,Christopher Vollmers,Megumi Hatori,Michael Witcher,Julie Secombe,Satchidananda Panda +6 more
TL;DR: Depletion of JARID1a in mammalian cells reduced Per promoter histone acetylation, dampened expression of canonical circadian genes, and shortened the period of circadian rhythms, indicating a nonredundant role in circadian oscillator function.