H
Hiroaki Imataka
Researcher at University of Hyogo
Publications - 88
Citations - 7391
Hiroaki Imataka is an academic researcher from University of Hyogo. The author has contributed to research in topics: Eukaryotic translation & EIF4E. The author has an hindex of 38, co-authored 85 publications receiving 6971 citations. Previous affiliations of Hiroaki Imataka include McGill University & Centre for Life.
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Journal ArticleDOI
Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E
Stéphane Pyronnet,Hiroaki Imataka,Anne-Claude Gingras,Rikiro Fukunaga,Tony Hunter,Nahum Sonenberg +5 more
TL;DR: It is shown that Mnk1 interacts with the C‐terminal region of the translational inhibitor p97, an eIF4G‐related protein that does not bind eif4E, raising the possibility that p97 can block phosphorylation of eIF2E by sequestering Mnk2, the recently cloned MAPK‐activated protein kinase.
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A newly identified N‐terminal amino acid sequence of human eIF4G binds poly(A)‐binding protein and functions in poly(A)‐dependent translation
TL;DR: Results indicate that, in addition to a recently identified mammalian PABP‐binding protein, PAIP‐1, eIF4G binds PABp and probably functions in poly(A)‐dependent translation in mammalian cells.
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Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase, GCN2
Mauro Costa-Mattioli,Delphine Gobert,Heather P. Harding,Barbara Herdy,Mounia Azzi,Martin A. Bruno,Michael Bidinosti,Cyrinne Ben Mamou,Edwige Marcinkiewicz,Madoka Yoshida,Hiroaki Imataka,A. Claudio Cuello,Nabil G. Seidah,Wayne S. Sossin,Jean-Claude Lacaille,David Ron,Karim Nader,Nahum Sonenberg +17 more
TL;DR: This study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway.
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Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
TL;DR: It is shown that eIF4GII, a recently discovered functional homolog of eIF 4GI, is more resistant to poliovirus-mediated cleavage than eif4GI, and that its proteolysis is concomitant with the shutoff of host cell protein synthesis.
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A Novel Functional Human Eukaryotic Translation Initiation Factor 4G
Alessandra Gradi,Hiroaki Imataka,Yuri V. Svitkin,Eran Rom,Brian Raught,Shigenobu Morino,Nahum Sonenberg +6 more
TL;DR: EIF4GII is a functional homolog of eIF4GI, which may have important implications for the understanding of the mechanism of shutoff of host protein synthesis following picornavirus infection.