R
Rikiro Fukunaga
Researcher at Osaka University
Publications - 43
Citations - 5889
Rikiro Fukunaga is an academic researcher from Osaka University. The author has contributed to research in topics: Granulocyte colony-stimulating factor receptor & Growth factor receptor. The author has an hindex of 28, co-authored 39 publications receiving 5717 citations. Previous affiliations of Rikiro Fukunaga include Osaka Bioscience Institute & Salk Institute for Biological Studies.
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Journal ArticleDOI
Rational design of potent antagonists to the human growth hormone receptor.
Germaine Fuh,Brian C. Cunningham,Rikiro Fukunaga,Shigekazu Nagata,David V. Goeddel,James A. Wells +5 more
TL;DR: Inactive hGH analogs were designed that were potent antagonists to hGH-induced cell proliferation and could be useful for treating clinical conditions of hGH excess, such as acromegaly.
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MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
Rikiro Fukunaga,Tony Hunter +1 more
TL;DR: Results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways.
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Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E
Stéphane Pyronnet,Hiroaki Imataka,Anne-Claude Gingras,Rikiro Fukunaga,Tony Hunter,Nahum Sonenberg +5 more
TL;DR: It is shown that Mnk1 interacts with the C‐terminal region of the translational inhibitor p97, an eIF4G‐related protein that does not bind eif4E, raising the possibility that p97 can block phosphorylation of eIF2E by sequestering Mnk2, the recently cloned MAPK‐activated protein kinase.
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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.
TL;DR: Mnk1 and Mnk2 are exclusive eIF4E kinases both in cultured fibroblasts and adult tissues, and they regulate inducible and constitutive eif4E phosphorylation, respectively.
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Dissecting eIF4E action in tumorigenesis
Hans-Guido Wendel,Ricardo L.A. Silva,Abba Malina,John R. Mills,Hong Zhu,Takeshi Ueda,Rie Watanabe-Fukunaga,Rikiro Fukunaga,Julie Teruya-Feldstein,Jerry Pelletier,Scott W. Lowe +10 more
TL;DR: Insight is provided into how eIF4E contributes to tumorigenesis and a level of translational control that may be suitable for therapeutic intervention is pinpointed.