H
Hiroeki Sahara
Researcher at Azabu University
Publications - 90
Citations - 1957
Hiroeki Sahara is an academic researcher from Azabu University. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 24, co-authored 89 publications receiving 1775 citations. Previous affiliations of Hiroeki Sahara include Toyo Suisan Kaisha, Ltd. & Sapporo Medical University.
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Journal ArticleDOI
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated
Atsushi Tanabe,Kenya Tanikawa,Mai Tsunetomi,Kaori Takai,Hiroto Ikeda,Junpei Konno,Toshihiko Torigoe,Hideki Maeda,Goro Kutomi,Kenji Okita,Mitsuru Mori,Hiroeki Sahara +11 more
TL;DR: It is suggested that the RNA helicase YTH DC2 contributes to colon tumor metastasis by promoting translation of HIF-1α and that YTHDC2 is potentially a diagnostic marker and target gene for treating colon cancer patients.
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Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma.
Satoshi Kawaguchi,Takuro Wada,Kazunori Ida,Yuriko Sato,Satoshi Nagoya,Tomohide Tsukahara,Sigeharu Kimura,Hiroeki Sahara,Hideyuki Ikeda,Kumiko Shimozawa,Hiroko Asanuma,Toshihiko Torigoe,Hiroaki Hiraga,Takeshi Ishii,Shin-ichiro Tatezaki,Noriyuki Sato,Toshihiko Yamashita +16 more
TL;DR: The findings indicate the safety of the SYT-SSX junction peptide in the use of vaccination and also give support to the property of the peptide to evoke in vivo immunological responses.
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Efficient Cross-Presentation by Heat Shock Protein 90-Peptide Complex-Loaded Dendritic Cells via an Endosomal Pathway
Takehiro Kurotaki,Yasuaki Tamura,Gosei Ueda,Gosei Ueda,Jun Oura,Goro Kutomi,Yoshihiko Hirohashi,Hiroeki Sahara,Toshihiko Torigoe,Hiroyoshi Hiratsuka,Hajime Sunakawa,Koichi Hirata,Noriyuki Sato +12 more
TL;DR: It is shown here that exogenous Hsp90-peptide complexes can gain access to the MHC class I presentation pathway and cause cross-presentation by bone marrow-derived dendritic cells, and it is demonstrated that immunization with Hsp 90-peptic complexes induce Ag-specific CD8+ T cell responses and strong antitumor immunity in vivo.
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In vivo anti-tumour effect of 3'-sulphonoquinovosyl 1'-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine
Hiroeki Sahara,M. Ishikawa,N Takahashi,S Ohtani,Noriyuki Sato,Shinsei Gasa,T Akino,Kokichi Kikuchi +7 more
TL;DR: The anti-tumour effect of sulphonoquinovosyl-lysoglyceride (A-5) is demonstrated, which provides important information that this sulpholipid could be a useful drug for cancer chemotherapy.
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Studies on inhibitors of mammalian DNA polymerase α and β: Sulfolipids from a pteridophyte, Athyrium niponicum
Yoshiyuki Mizushina,Itiro Watanabe,Keisuke Ohta,Masaharu Takemura,Hiroeki Sahara,Nobuaki Takahashi,Sinsei Gasa,Fumio Sugawara,Akio Matsukage,Shonen Yoshida,Kengo Sakaguchi +10 more
TL;DR: Three sulfolipid compounds have been isolated from a higher plant, a pteridophyte, Athyrium niponicum, as potent inhibitors of the activities of calf DNA polymerase α and ratDNA polymerase β, and showed that DNA polymerases α and β were inhibited non-competitively with respect to the DNA template and substrate.