H
Hirofumi Matsui
Researcher at University of Tsukuba
Publications - 181
Citations - 4630
Hirofumi Matsui is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Reactive oxygen species & Apoptosis. The author has an hindex of 37, co-authored 168 publications receiving 4061 citations. Previous affiliations of Hirofumi Matsui include Kobe University & National Institute for Materials Science.
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Journal ArticleDOI
A mitochondrial superoxide theory for oxidative stress diseases and aging
Hiroko P. Indo,Hsiu-Chuan Yen,Ikuo Nakanishi,Ken-ichiro Matsumoto,Masato Tamura,Yumiko Nagano,Hirofumi Matsui,Oleg Gusev,Richard Cornette,Takashi Okuda,Yukiko Minamiyama,Hiroshi Ichikawa,Shigeaki Suenaga,Misato Oki,Tsuyoshi Sato,Toshihiko Ozawa,Daret K. St. Clair,Hideyuki J. Majima +17 more
TL;DR: Based on research conducted after Fridovich’s seminal studies, a modified superoxide theory is proposed, i.e., superoxide is the origin of reactive oxygen and nitrogen species (RONS) and, as such, causes various redox related diseases and aging.
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The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine
TL;DR: The defense mechanisms of stomach, and the pathophysiology of non-steroidal anti-inflammatory drugs-induced injury of stomach and small intestine are discussed, especially focused on non-stersoidalAnti- inflammatory drugs’ action on mitochondria.
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TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.
Shigeo Mori,Koichi Matsuzaki,Katsunori Yoshida,Fukiko Furukawa,Yoshiya Tahashi,Hideo Yamagata,Go Sekimoto,Toshihito Seki,Hirofumi Matsui,Mikio Nishizawa,Jun-ichi Fujisawa,Kazuichi Okazaki +11 more
TL;DR: It is shown that either HGF or TGF-β treatment of normal stomach-origin cells activated the JNK pathway, thereafter inducing endogenous R-Smads phosphorylated at linker regions, which were the common phosphorylation sites for HGF and T GF-β signaling pathways.
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An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice.
TL;DR: An orally administered nitroxide radical-containing nanoparticle (RNP(O) that accumulates specifically in the colons of mice with colitis is more effective in reducing inflammation than low-molecular-weight TEMPOL or mesalamine.
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Mechanisms involved in δ-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: Relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin
Yoshiko Ohgari,Yuki Nakayasu,Sakihito Kitajima,Mari Sawamoto,Hajime Mori,Osamu Shimokawa,Hirofumi Matsui,Shigeru Taketani +7 more
TL;DR: Not only the low level of ferrochelatase but also the augmented uptake of ALA contributes to the ALA-induced accumulation of protoporphyrin IX and subsequent photo-damage in cancer cells.