S
Shigeru Taketani
Researcher at Kyoto Institute of Technology
Publications - 122
Citations - 4455
Shigeru Taketani is an academic researcher from Kyoto Institute of Technology. The author has contributed to research in topics: Heme & Ferrochelatase. The author has an hindex of 33, co-authored 121 publications receiving 4082 citations. Previous affiliations of Shigeru Taketani include Kansai Medical University.
Papers
More filters
Journal ArticleDOI
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.
Kazuhiro Ogawa,Jiying Sun,Jiying Sun,Shigeru Taketani,Osamu Nakajima,Chiaki Nishitani,Shigeru Sassa,Norio Hayashi,Masayuki Yamamoto,Shigeki Shibahara,Hiroyoshi Fujita,Kazuhiko Igarashi +11 more
TL;DR: It is shown that heme binds specifically to Bach1 and regulates its DNA‐binding activity, suggesting that increased levels of heme inactivate the repressor Bach1, resulting in induction of a host of genes with MAREs.
Journal ArticleDOI
Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation
Kiyo-aki Ishii,Toshio Fumoto,Kazuhiro Iwai,Kazuhiro Iwai,Sunao Takeshita,Masako Ito,Nobuyuki Shimohata,Nobuyuki Shimohata,Hiroyuki Aburatani,Shigeru Taketani,Christopher J. Lelliott,Antonio Vidal-Puig,Kyoji Ikeda +12 more
TL;DR: Ikeda et al. as discussed by the authors showed that the combined action of iron uptake and a key transcription factor involved in mitochondrial biogenesis are required for the proper functioning of these cells and that in cases of increased bone loss, iron chelation may be beneficial by inhibiting these cells.
Journal ArticleDOI
Mitochondrial function provides instructive signals for activation-induced B-cell fates.
Kyoung Jin Jang,Hiroto Mano,Koji Aoki,Tatsunari Hayashi,Akihiko Muto,Yukiko Nambu,Katsu Takahashi,Katsuhiko Itoh,Shigeru Taketani,Stephen L. Nutt,Kazuhiko Igarashi,Akira Shimizu,Manabu Sugai +12 more
TL;DR: Identifying mROS as a haeme synthesis regulator increases the understanding of mechanisms regulating haeme homeostasis and cell fate determination after B-cell activation.
Journal ArticleDOI
Mechanisms involved in δ-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: Relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin
Yoshiko Ohgari,Yuki Nakayasu,Sakihito Kitajima,Mari Sawamoto,Hajime Mori,Osamu Shimokawa,Hirofumi Matsui,Shigeru Taketani +7 more
TL;DR: Not only the low level of ferrochelatase but also the augmented uptake of ALA contributes to the ALA-induced accumulation of protoporphyrin IX and subsequent photo-damage in cancer cells.
Journal ArticleDOI
Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species
TL;DR: Oxidative stress and the generation of reactive oxygen species (ROS) have been implicated in the pathogenesis of cellular damage and oxidation of 2′,7′‐dichlorodihydrofluorescin diacetate (DCFH‐DA) is reported in terms of oxidation of a reporter molecule.