Hirohiko Kamiyama

TL;DR: It is found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations, which defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67 to 100% of the tumors.

TL;DR: Isolated AMD lesions are genetically distinct from those associated with PanINs, and the latter may represent retrograde extension of the neoplastic PanIN cells or less likely are precursors to PanIN.

TL;DR: A molecular assay to quantify the relative contributions of human and mouse in mixed DNA samples is developed and how contaminating mouse DNA affects next-generation DNA sequencing is discussed.

TL;DR: Chemotherapy can be personalized using patient-specific cell lines derived in biochemically selectable mice, as shown by high-throughput chemosensitivity testing of low-passage cancer cell lines from primary cancers.

TL;DR: In vivo and in vitro growth of selected IPMNs were attempted based on the hypothesis that IPMNs could be grown in the most severely immunodeficient mice, and one IPMNs, with an associated invasive carcinoma, was successfully established as a cell line.