K
Kimberly Walter
Researcher at Genentech
Publications - 50
Citations - 7583
Kimberly Walter is an academic researcher from Genentech. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 28, co-authored 47 publications receiving 7057 citations. Previous affiliations of Kimberly Walter include Johns Hopkins University.
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Journal ArticleDOI
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Siân Jones,Xiaosong Zhang,D. Williams Parsons,D. Williams Parsons,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,Hirohiko Kamiyama,Antonio Jimeno,Seung-Mo Hong,Baojin Fu,Ming Tseh Lin,Eric S. Calhoun,Mihoko Kamiyama,Kimberly Walter,Tatiana Nikolskaya,Yuri Nikolsky,James Hartigan,Douglas Smith,Manuel Hidalgo,Steven D. Leach,Alison P. Klein,Elizabeth M. Jaffee,Michael Goggins,Anirban Maitra,Anirban Maitra,Christine A. Iacobuzio-Donahue,James R. Eshleman,Scott E. Kern,Ralph H. Hruban,Rachel Karchin,Nickolas Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +37 more
TL;DR: It is found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations, which defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67 to 100% of the tumors.
Journal ArticleDOI
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
Christine A. Iacobuzio-Donahue,Anirban Maitra,Mari Olsen,Anson W. Lowe,N. Tjarda van Heek,Christophe Rosty,Kimberly Walter,Norihiro Sato,Antony R. Parker,Raheela Ashfaq,Elizabeth M. Jaffee,Byungwoo Ryu,Jessa Jones,James R. Eshleman,Charles J. Yeo,John L. Cameron,Scott E. Kern,Ralph H. Hruban,Patrick O. Brown,Michael Goggins +19 more
TL;DR: The genes and expressed sequence tags presented in this study provide clues to the pathobiology of pancreatic cancer and implicate a large number of potentially new molecular markers for the detection and treatment of Pancreatic cancer.
Journal ArticleDOI
Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology
Christine A. Iacobuzio-Donahue,Anirban Maitra,Grace L. C. Shen-Ong,Tjarda van Heek,Raheela Ashfaq,Renee Meyer,Kimberly Walter,Karin D. Berg,Michael A. Hollingsworth,John L. Cameron,Charles J. Yeo,Scott E. Kern,Michael Goggins,Ralph H. Hruban +13 more
TL;DR: One hundred eighty fragments were identified as having fivefold or greater expression levels in pancreas cancer specimens as compared to normal tissue, of which 124 corresponded to known genes and 56 to ESTs.
Journal ArticleDOI
Pancreatic Cancers Epigenetically Silence SIP1 and Hypomethylate and Overexpress miR-200a/200b in Association with Elevated Circulating miR-200a and miR-200b Levels
Ang Li,Noriyuki Omura,Seung-Mo Hong,Audrey Vincent,Kimberly Walter,Margaret Griffith,Michael Borges,Michael Goggins +7 more
TL;DR: Most pancreatic cancers display hypomethylation and overexpression of miR-200a and miR -200b, silencing of SIP1 by promoter methylation, and retention of E-cadherin expression, which could have diagnostic utility.
Journal ArticleDOI
Quantitative comparison of DNA methylation assays for biomarker development and clinical applications
Christoph Bock,Florian Halbritter,Francisco J. Carmona,Sascha Tierling,Paul Datlinger,Yassen Assenov,María Berdasco,Anke K. Bergmann,Keith Booher,Florance Busato,Mihaela Campan,Christina Dahl,Christina M. Dahmcke,Dinh Diep,Agustín F. Fernández,Clarissa Gerhäuser,Andrea Haake,Katharina Heilmann,Thomas Holcomb,Dianna Hussmann,Mitsuteru Ito,Ruth Kläver,Martin Kreutz,Marta Kulis,Virginia Lopez,Shalima S. Nair,Dirk S. Paul,Nongluk Plongthongkum,Wenija Qu,Ana C. Queirós,Frank Reinicke,Guido Sauter,Thorsten Schlomm,Aaron L. Statham,Clare Stirzaker,Ruslan Strogantsev,Rocío G. Urdinguio,Kimberly Walter,Dieter Weichenhan,Daniel J. Weisenberger,Stephan Beck,Susan J. Clark,Manel Esteller,Anne C. Ferguson-Smith,Mario F. Fraga,Per Guldberg,Lise Lotte Hansen,Peter W. Laird,José I. Martín-Subero,Anders O. H. Nygren,Ralf Peist,Christoph Plass,David S. Shames,Reiner Siebert,Xueguang Sun,Jörg Tost,Jörn Walter,Kun Zhan +57 more
TL;DR: The results of a community-wide benchmarking study comparing the performance of all widely used methods for DNA methylation analysis that are compatible with routine clinical use are described, with amplicon bisulfite sequencing and bisulfITE pyrosequencing showing the best all-round performance.