H
Hirokazu Shigematzu
Researcher at Harvard University
Publications - 1
Citations - 246
Hirokazu Shigematzu is an academic researcher from Harvard University. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 1, co-authored 1 publications receiving 233 citations.
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MOZ-TIF2, but Not BCR-ABL, Confers Properties of Leukemic Stem Cells to Committed Murine Hematopoietic Progenitors.
Brian J. P. Huntly,Hirokazu Shigematzu,Kenji Deguchi,Benjamin H. Lee,Shinichi Mizuno,Nicky Duclos,Rebecca Rowan,Sonia M Amaral,David P. Curley,Ifor R. Williams,Koichi Akashi,Gary Gilliland +11 more
TL;DR: In this article, the authors tested the ability of representative leukemia oncogenes to transform committed myeloid progenitor cells that lack the capacity for self-renewal, and showed that an active MOZ-TIF2, but not BCR-ABL, can collaborate with mutations induced by retroviral mutagenesis to confer properties of leukemic stem cells to committed progenitors.