Shinichi Mizuno

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: It is demonstrated that some, but not all, leukemia oncogenes can confer properties of leukemic stem cells to hematopoietic progenitors destined to undergo apoptotic cell death.

TL;DR: Myeloid leukemia–1 (MCL-1) is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitor populations, including HSCs.

TL;DR: HSCs express PU.1, and its constitutive expression is necessary for maintenance of the HSC pool in the bone marrow, which plays indispensable and distinct roles in hematopoietic development through supporting HSC self-renewal as well as commitment and maturation of myeloid and lymphoid lineages.

TL;DR: DNMTs were substantially overexpressed in leukemia cells in a leukemia type- and stage-specific manner and it was observed that the p15(INAK4B) gene, a cell cycle regulator, was methylated in 24 of 33 (72%) cases of AML.