H
Hiroko Tadokoro
Researcher at University of Tokyo
Publications - 7
Citations - 823
Hiroko Tadokoro is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cancer cell & Cancer research. The author has an hindex of 4, co-authored 4 publications receiving 667 citations. Previous affiliations of Hiroko Tadokoro include Tokyo University of Pharmacy and Life Sciences & Tokyo Medical University.
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Journal ArticleDOI
Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
Tomohiro Umezu,Hiroko Tadokoro,Kenko Azuma,Seiichiro Yoshizawa,Kazuma Ohyashiki,Junko H. Ohyashiki +5 more
TL;DR: This in vitro HR myeloma cell model will be useful for investigating MM cell-endothelial cell interactions under hypoxic conditions, which may mimic the in vivo bone marrow microenvironment.
Journal ArticleDOI
Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells
Hiroko Tadokoro,Hiroko Tadokoro,Tomohiro Umezu,Kazuma Ohyashiki,Toshihiko Hirano,Junko H. Ohyashiki +5 more
TL;DR: It is demonstrated that cancer cells and their exosomes have altered miRNA profiles under hypoxic conditions, including miR-210, which affected the behavior of endothelial cells.
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Effects of vitamin K3 and K5 on proliferation, cytokine production, and regulatory T cell-frequency in human peripheral-blood mononuclear cells
Hiroshige Hatanaka,Hitomi Ishizawa,Yurie Nakamura,Hiroko Tadokoro,Sachiko Tanaka,Kenji Onda,Kentaro Sugiyama,Toshihiko Hirano +7 more
TL;DR: The data suggest that VK3 and VK5 attenuate T cell mediated immunity by inhibiting the proliferative response and inducing apoptosis in activated T cells.
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Antiproliferative and anti-invasive effects of inorganic and organic arsenic compounds on human and murine melanoma cells in vitro.
Yoko Hiwatashi,Hiroko Tadokoro,Kayo Henmi,Mariko Arai,Toshikazu Kaise,Sachiko Tanaka,Toshihiko Hirano +6 more
TL;DR: Examination of the effects of two inorganic and six organic arsenic compounds on cell proliferation and cell invasion of melanoma cells in vitro finds no treatment options available that provide sufficient response rates or a significant prolongation of overall survival.
Journal ArticleDOI
Bone marrow adipocytes induce cancer‐associated fibroblasts and immune evasion, enhancing invasion and drug resistance
Shinya Sato,Toru Hiruma,Mitsuyuki Koizumi,Mitsuyo Yoshihara,Yoshiyasu Nakamura,Hiroko Tadokoro,Sadako Motomatsu,Takashi Yamanaka,Kota Washimi,Yoichiro Okubo,Emi Yoshioka,Rika Kasajima,Toshinari Yamashita,Takeshi Kishida,Tomoyuki Yokose,Yohei Miyagi +15 more
TL;DR: In this article , the role of bone marrow adipocytes on cancer cells was investigated by focusing on an invasive front that reflects the direct effects of stromal cells on cancer, and compared invasive fronts with adipocyte-rich bone marrow (adipo‐BM) to those with hematopoietic cell-rich (hemato-BM) as a normal counterpart of adipocytes.