Hiroo Ogura

TL;DR: The data suggest that BRS-3 is required for the regulation of endocrine processes and metabolism responsible for energy balance and adiposity, and provides a useful new model for the investigation of human obesity and associated diseases.

TL;DR: Donepezil showed several positive characteristics including the following: It has a novel structure compared to other conventional ChE inhibitors; it shows strong anti-AChE activity and has long lasting efficacy; the inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility.

TL;DR: A cyclic amine compound is defined by the formula: ##STR1## in which J is indanyl, indanonyl, indenyl, indeneryl, benzosuberonyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is --(CHR22)r--, R22 being H or methyl,

TL;DR: In wild-type mice, RyR3-mediated intracellular Ca2+ ([Ca2+]i) release from endoplasmic reticulum (ER) may inhibit hippocampal LTP and spatial learning, suggesting the role in synaptic plasticity of ryanodine receptor type 3 is evaluated.

TL;DR: Results indicate that donepezil enhances and scopolamine suppresses the survival of newborn cells in the DG via CREB signaling without affecting neural progenitor cell proliferation and the neuronal differentiation.