S
Shigeyoshi Itohara
Researcher at RIKEN Brain Science Institute
Publications - 255
Citations - 29924
Shigeyoshi Itohara is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Matrix metalloproteinase & Hippocampal formation. The author has an hindex of 85, co-authored 251 publications receiving 27656 citations. Previous affiliations of Shigeyoshi Itohara include Kyoto University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Gabriele Bergers,Rolf A. Brekken,Gerald McMahon,Thiennu H. Vu,Takeshi Itoh,Kazuhiko Tamaki,Kazuhiko Tanzawa,Philip E. Thorpe,Shigeyoshi Itohara,Zena Werb,Douglas Hanahan +10 more
TL;DR: The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.
Journal ArticleDOI
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Peter Mombaerts,Alan Richard Clarke,Michael A. Rudnicki,John Iacomini,Shigeyoshi Itohara,Juan J. Lafaille,Lili Wang,Yoshiaki Ichikawa,Rudolf Jaenisch,Martin L. Hooper,Susumu Tonegawa +10 more
TL;DR: Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocyte to CD4+CD8+ thymocytes, as well as for the expansion of the pool ofCD4+ CD8+ cells.
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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
Qing Lin Li,Kosei Ito,Chohei Sakakura,Hiroshi Fukamachi,Ken-ichi Inoue,Xin Zi Chi,Kwang Youl Lee,Shintaro Nomura,Chang Woo Lee,Sang-Bae Han,Hwan Mook Kim,Wun-Jae Kim,Hiromitsu Yamamoto,Namiko Yamashita,Takashi Yano,Toshio Ikeda,Shigeyoshi Itohara,Johji Inazawa,Tatsuo Abe,Akeo Hagiwara,Hisakazu Yamagishi,Asako Ooe,Atsushi Kaneda,Takashi Sugimura,Toshikazu Ushijima,Suk Chul Bae,Yoshiaki Ito +26 more
TL;DR: Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory and apoptosis-inducing action of TGF-beta, indicating that Runx3 is a major growth regulator of gastric epithelium.
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Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Itaru Imayoshi,Masayuki Sakamoto,Toshiyuki Ohtsuka,Keizo Takao,Keizo Takao,Tsuyoshi Miyakawa,Tsuyoshi Miyakawa,Masahiro Yamaguchi,Kensaku Mori,Toshio Ikeda,Shigeyoshi Itohara,Ryoichiro Kageyama +11 more
TL;DR: It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.
Journal Article
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.
Takeshi Itoh,Masatoshi Tanioka,Hiroshi Yoshida,Takayuki Yoshioka,Hirofumi Nishimoto,Shigeyoshi Itohara +5 more
TL;DR: It is indicated that host-derived gelatinase A plays an important role in angiogenesis and tumor progression, suggesting the usefulness of gelatin enzyme A inhibitors for anticancer chemotherapy.