Hiroshi Inano

TL;DR: Curcumin has a potent preventive activity during the DES-dependent promotion stage of radiation-induced mammary tumorigenesis, and whole mounts of the mammary glands showed that curcumin yielded morphologically indistinguishable proliferation and differentiation from the glands of the control rats.

TL;DR: Curcumin does not have any side-effects and is an effective agent for chemoprevention acting at the radiation-induced initiation stage of mammary tumorigenesis, and no change in litter size and body weight of pups born from curcumin-fed rats indicated no toxicity of Curcumin.

TL;DR: It is demonstrated that curcumin can be used as an effective radioprotective agent to inhibit acute and chronic effects, but not mortality, after irradiation.

TL;DR: The enzymic pattern unique to the testes of immature rats would seem to be the significantly strong activities of the Δ4- androstene and -pregnene-5α-reductase, the 5α-androstane-3-dione, and 3β-hydroxy- 5 α-androstan-17-one as metabolites of both substrates.

TL;DR: Results indicate that curcumin has the ability to inhibit iNOS induction by LPS in the mammary gland and to scavenge NO radicals, which might explain, at least partly, its therapeutic properties in inflammation of the Mammary gland.