Hiroshi Yoshikura

TL;DR: The results suggest that HCV does induce antivirion antibody, as measured by blocking of initiation of the replication cycle of virus in cells and by the formation of immunoprecipitable antigen-antibody complexes but that these antibodies are isolate specific and change over time.

TL;DR: Examination of serial sera from a chimpanzee infected with HCV revealed parallel changes in the buoyant density and immunoprecipitability of HCV-associated RNA during the course of infection, suggesting that HCV is bound to anti-HCV antibodies as antigen-antibody complexes in chronic hepatitis C.

TL;DR: It appears likely that the HCV genome can replicate in the human T-cell line MOLT-4, and immunofluorescence tests with antibodies specific for HCV core and NS4 antigens showed that MOLt-4 Ma cells were positive for viral antigen 7 days after inoculation.

TL;DR: The sensitivity in detecting HPV DNA was even better than that obtained by using Southern blot analysis, and the PCR with the consensus primers for LI region (Ll‐PCR) could amplify at least nine genital HPV types and could be typed by subsequent restriction mapping.

TL;DR: The study demonstrated that neutralization of HCV was mediated, in part, by isolate-specific antibody recognizing HVR1, a principal neutralization epitope within the putative envelope of hepatitis C virus.