Hirosuke Sugahara

TL;DR: Analysis of gut microbiota composition in newborn to centenarian Japanese subjects revealed certain transition types of microbiota were enriched in infants, adults, elderly individuals and both infant and elderly subjects, and transporter property prediction results suggest that nutrients in the gut might play an important role in changing the Gut microbiota composition with age.

TL;DR: Administration of B. breve A1 to AD mice reversed the impairment of alternation behavior in a Y maze test and the reduced latency time in a passive avoidance test, indicating that it prevented cognitive dysfunction, and it was demonstrated that non-viable components of the bacterium or its metabolites partially ameliorated the cognitive decline observed in AD mice.

TL;DR: Results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity.

TL;DR: NMR-based metabolomics showed significantly increased fecal levels of pimelate, a precursor of biotin, and butyrate in the BB536-HGM group and metatranscriptomic analysis of fecal microbiota followed by in vitro bioassay indicated that the elevated biotin level was due to an alteration in metabolism related to biotin synthesis by Bacteroides caccae in this mouse model.

TL;DR: The results revealed the patterns and transition points with respect to compositional changes of Bifidobacterium species that occur with ageing, and the findings indicate that there may be symbiotic associations between some of these species in the gut microbiota.