J
Jun Kikuchi
Researcher at Yokohama City University
Publications - 175
Citations - 11085
Jun Kikuchi is an academic researcher from Yokohama City University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 39, co-authored 154 publications receiving 8933 citations. Previous affiliations of Jun Kikuchi include University of Tokyo & Nagoya University.
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Journal ArticleDOI
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa,Yuuki Obata,Shinji Fukuda,Takaho A. Endo,Gaku Nakato,Daisuke Takahashi,Yumiko Nakanishi,Chikako Uetake,Keiko Kato,Tamotsu Kato,Masumi Takahashi,Noriko N. Fukuda,Shinnosuke Murakami,Eiji Miyauchi,Shingo Hino,Koji Atarashi,Satoshi Onawa,Yumiko Fujimura,Trevor Lockett,Julie M. Clarke,David L. Topping,Masaru Tomita,Shohei Hori,Osamu Ohara,Tatsuya Morita,Haruhiko Koseki,Jun Kikuchi,Kenya Honda,Koji Hase,Hiroshi Ohno +29 more
TL;DR: It is shown that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice and ameliorated the development of colitis induced by adoptive transfer of CD4+ CD45RBhi T cells in Rag1−/− mice.
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Bifidobacteria can protect from enteropathogenic infection through production of acetate
Shinji Fukuda,Hidehiro Toh,Koji Hase,Kenshiro Oshima,Yumiko Nakanishi,Kazutoshi Yoshimura,Toru Tobe,Julie M. Clarke,David L. Topping,Tohru Suzuki,Todd D. Taylor,Kikuji Itoh,Jun Kikuchi,Jun Kikuchi,Hidetoshi Morita,Masahira Hattori,Hiroshi Ohno,Hiroshi Ohno +17 more
TL;DR: It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
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Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production
Hidetoshi Morita,Hidehiro Toh,Shinji Fukuda,Hiroshi Horikawa,Kenshiro Oshima,Takehito Suzuki,Masaru Murakami,Shin Hisamatsu,Yukio Kato,Tatsuya Takizawa,Hideo Fukuoka,Tetsuhiko Yoshimura,Kikuji Itoh,Daniel J. O'Sullivan,Larry L. McKay,Hiroshi Ohno,Jun Kikuchi,Jun Kikuchi,Toshio Masaoka,Masahira Hattori +19 more
TL;DR: Two-dimensional nuclear magnetic resonance (2D-NMR) with 13C3-glycerol demonstrated that L. reuteri JCM 1112T could convert glycerol to reuterin in vivo, substantiating the potential of L.ReuteriJCM 11 12T to produce reuterIn in the intestine.
Journal ArticleDOI
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain
Eri Sakata,Yoshiki Yamaguchi,Eiji Kurimoto,Jun Kikuchi,Shigeyuki Yokoyama,Shingo Yamada,Hiroyuki Kawahara,Hideyoshi Yokosawa,Nobutaka Hattori,Yoshikuni Mizuno,Keiji Tanaka,Koichi Kato +11 more
TL;DR: The findings suggest that the Arg 42 mutation induces a conformational change in the Rpn10‐binding site of Ubl, resulting in impaired proteasomal binding of parkin, which could be the cause of AR‐JP.
Journal ArticleDOI
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.
TL;DR: There is direct evidence to indicate that the biosynthetic pathway for phytosterol via lanosterol exists in plant cells, and the pathway is designated “the Lanosterol pathway.”