Hirotaka Osada

TL;DR: Findings clearly suggest that marked overexpression of the miR-17-92 cluster with occasional gene amplification may play a role in the development of lung cancers, especially in their most aggressive form, small-cell lung cancer, and that the C13orf25 gene may well be serving as a vehicle in this regard.

TL;DR: It is shown that in erythroid cells Lmo2 forms a novel DNA‐binding complex, with GATA‐1, TAL1 and E2A, and the recently identified LIM‐binding protein Ldb1/NLI, which may play a role in haematopoiesis.

TL;DR: Findings suggest that although JV18-1 and DPC4 may play roles in a limited fraction of lung cancers, another tumor suppressor gene may also exist in this chromosome region.

TL;DR: It is demonstrated, using anti-RBTN2 and anti-TAL1 antisera, that the LIM protein RBTN2 is not phosphorylated and is complexed with the TAL1 phosphoprotein in the nucleus of erythroid cells, providing a direct link between proteins activated by chromosomal translocations in T-cell acute leukemia.

TL;DR: It is shown here that LOI of H19 is also a frequent event in lung cancer development, and correlated with hypomethylation of the promoter region, and overexpression of H 19 is often associated with LOIof H19 in lung cancers retaining both parental alleles.