A
Alan J. Warren
Researcher at University of Cambridge
Publications - 72
Citations - 8581
Alan J. Warren is an academic researcher from University of Cambridge. The author has contributed to research in topics: Ribosome & Gene. The author has an hindex of 34, co-authored 60 publications receiving 7817 citations. Previous affiliations of Alan J. Warren include Laboratory of Molecular Biology & Cambridge University Hospitals NHS Foundation Trust.
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Journal ArticleDOI
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.
Linda M. Scott,Wei Tong,Ross L. Levine,Michael A. Scott,Philip A. Beer,Michael R. Stratton,P. Andrew Futreal,Wendy N. Erber,Mary Frances McMullin,Claire N. Harrison,Alan J. Warren,Alan J. Warren,D. Gary Gilliland,D. Gary Gilliland,Harvey F. Lodish,Anthony R. Green,Anthony R. Green +16 more
TL;DR: Four somatic gain-of-function mutations affecting JAK2 exon 12 define a distinctive myeloproliferative syndrome that affects patients who currently receive a diagnosis of polycythemia vera or idiopathic erythrocytosis.
Journal ArticleDOI
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
Elli Papaemmanuil,Mario Cazzola,Jacqueline Boultwood,Luca Malcovati,Paresh Vyas,David T. Bowen,Andrea Pellagatti,J. S. Wainscoat,Eva Hellström-Lindberg,Carlo Gambacorti-Passerini,Anna L. Godfrey,I. Rapado,Ana Cvejic,Ana Cvejic,Richard Rance,C. McGee,Peter R. Ellis,Laura Mudie,Phil Stephens,Stuart McLaren,Charles E. Massie,Patrick S. Tarpey,Ignacio Varela,Serena Nik-Zainal,Helen Davies,Adam Shlien,David T. Jones,Keiran Raine,Jonathon Hinton,Adam Butler,Jon W. Teague,E J Baxter,Joannah Score,Anna Gallì,M.G. Della Porta,Erica Travaglino,Michael J. Groves,Sudhir Tauro,Nikhil C. Munshi,Nikhil C. Munshi,KC Anderson,Adel K. El-Naggar,Andrej Fischer,Andrej Fischer,Ville Mustonen,Alan J. Warren,Nicholas C.P. Cross,Anthony R. Green,P A Futreal,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +51 more
TL;DR: Mutations in SF3B1 implicate abnormalities of messenger RNA splicing in the pathogenesis of myelodysplastic syndromes and were associated with down-regulation of key gene networks, including core mitochondrial pathways.
Journal ArticleDOI
The oncogenic cysteine-rich lim domain protein rbtn2 is essential for erythroid development
Alan J. Warren,William H. Colledge,Mark B. L. Carlton,Martin J. Evans,Andrew J.H. Smith,Terence H. Rabbitts +5 more
TL;DR: In vitro differentiation of yolk sac tissue from homozygous mutant mice and sequentially targeted double-mutant ES cells demonstrates a block to erythroid development, which shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erystroid differentiation.
Journal ArticleDOI
An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes
Javier Corral,Isabelle Lavenir,Helen Impey,Alan J. Warren,Alan Forster,Teresa A Larson,Sarah Bell,Andrew N. J. McKenzie,Gareth King,Terence H. Rabbitts +9 more
TL;DR: This novel use of homologous recombination formally proves that chromosomal translocations contribute to malignancy and provides a general strategy to create fusion oncogenes for studying their role in tumorigenesis.
Journal ArticleDOI
A new system for naming ribosomal proteins
Nenad Ban,Roland Beckmann,Jamie H. D. Cate,Jonathan D. Dinman,François Dragon,Steven R. Ellis,Denis L. J. Lafontaine,Lasse Lindahl,Anders Liljas,Jeffrey M. Lipton,Michael A. McAlear,Peter B. Moore,Harry F. Noller,Joaquin Ortega,Vikram Govind Panse,Venki Ramakrishnan,Christian M. T. Spahn,Thomas A. Steitz,Marek Tchórzewski,David Tollervey,Alan J. Warren,James R. Williamson,Daniel N. Wilson,Ada Yonath,Marat Yusupov +24 more
TL;DR: A system for naming ribosomal proteins is described, designed so that new names are similar enough to old names to be easily recognized, but are written in a format that unambiguously identifies them as 'new system' names.