R. Baer

TL;DR: Nine T cell gamma variable (V) gene segments isolated from human DNA show that major rearrangements can be observed that are attributable to the five active V gamma genes, and human cells with the phenotype of helper T cells can undergo productive V gamma-J gamma joining.

TL;DR: The nucleotide sequence of a translocated c-myc gene in a Burkitt lymphoma reveals multiple base changes in the coding region, probably the result of somatic mutations that occurred during and after translocation, and may contribute to oncogenesis by allowing synthesis of an altered c- myc gene product.

TL;DR: Interaction between these two proteins can alter T cell development and potentiate tumorigenesis, and provide formal proof that TAL1 is an oncogene, apparently acting as a tumour promoter in this system.

TL;DR: It is demonstrated, using anti-RBTN2 and anti-TAL1 antisera, that the LIM protein RBTN2 is not phosphorylated and is complexed with the TAL1 phosphoprotein in the nucleus of erythroid cells, providing a direct link between proteins activated by chromosomal translocations in T-cell acute leukemia.

TL;DR: The structure of the alpha-chain genes in a T cell line harboring the chromosome 14 inversion is investigated and it is found that the VH-J alpha C alpha rearrangement is productive at the genomic level and therefore may encode a hybrid immunoglobulin/T cell receptor polypeptide.