H
Hiroto Ishikawa
Researcher at Hyogo College of Medicine
Publications - 78
Citations - 3169
Hiroto Ishikawa is an academic researcher from Hyogo College of Medicine. The author has contributed to research in topics: Visual acuity & Stem cell. The author has an hindex of 22, co-authored 70 publications receiving 2830 citations. Previous affiliations of Hiroto Ishikawa include University of South Florida & Kyoto University.
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Journal ArticleDOI
Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
Mari Dezawa,Hiroshi Kanno,Mikio Hoshino,Hirotomi Cho,Naoya Matsumoto,Yutaka Itokazu,Nobuyoshi Tajima,Hitoshi Yamada,Hajime Sawada,Hiroto Ishikawa,Toshirou Mimura,Masaaki Kitada,Yoshihisa Suzuki,Chizuka Ide +13 more
TL;DR: It is shown that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach.
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Bone marrow stromal cells generate muscle cells and repair muscle degeneration.
Mari Dezawa,Hiroto Ishikawa,Yutaka Itokazu,Tomoyuki Yoshihara,Mikio Hoshino,Shin'ichi Takeda,Chizuka Ide,Yo-ichi Nabeshima +7 more
TL;DR: A method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%, which represents a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.
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Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model.
Sandra Acosta,Naoki Tajiri,Kazutaka Shinozuka,Hiroto Ishikawa,Bethany Grimmig,Bethany Grimmig,David M. Diamond,Paul R. Sanberg,Paula C. Bickford,Paula C. Bickford,Yuji Kaneko,Cesario V. Borlongan +11 more
TL;DR: Results indicate a progressive deterioration of the TBI brain over time characterized by elevated inflammation and suppressed neurogenesis, and Therapeutic intervention at the chronic stage of TBI may confer abrogation of these deleterious cell death processes.
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Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Brain from Traumatic Brain Injury-Induced Neurodegeneration and Motor and Cognitive Impairments: Cell Graft Biodistribution and Soluble Factors in Young and Aged Rats
Naoki Tajiri,Sandra Acosta,M. Shahaduzzaman,Hiroto Ishikawa,Kazutaka Shinozuka,Mibel Pabon,Diana G. Hernandez-Ontiveros,D. W. Kim,Christopher Metcalf,Meaghan Staples,Travis Dailey,Julie Vasconcellos,Giorgio Franyuti,Lisa J. Gould,Niketa A. Patel,Niketa A. Patel,Denise R. Cooper,Denise R. Cooper,Yuji Kaneko,Cesar V. Borlongan,Paula C. Bickford +20 more
TL;DR: Human adipose-derived stem cells are promising therapeutic cells for TBI, and lncRNAs in the secretome is an important mechanism of cell therapy, although hADSCs showed reduced efficacy in aged rats, which may in part result from decreased homing of the cells to the spleen.
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Peripheral nerve regeneration by the in vitro differentiated-human bone marrow stromal cells with Schwann cell property.
TL;DR: It is suggested that human MSCs can be induced to be a substitute for Schwann cells that may be applied for nerve regeneration.