M
Mikio Hoshino
Researcher at Tokyo Medical and Dental University
Publications - 142
Citations - 8561
Mikio Hoshino is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Cerebellum & Guanine nucleotide exchange factor. The author has an hindex of 46, co-authored 133 publications receiving 7642 citations. Previous affiliations of Mikio Hoshino include Kyoto University & National Presto Industries.
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Journal ArticleDOI
Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
Mari Dezawa,Hiroshi Kanno,Mikio Hoshino,Hirotomi Cho,Naoya Matsumoto,Yutaka Itokazu,Nobuyoshi Tajima,Hitoshi Yamada,Hajime Sawada,Hiroto Ishikawa,Toshirou Mimura,Masaaki Kitada,Yoshihisa Suzuki,Chizuka Ide +13 more
TL;DR: It is shown that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach.
Journal ArticleDOI
Bone marrow stromal cells generate muscle cells and repair muscle degeneration.
Mari Dezawa,Hiroto Ishikawa,Yutaka Itokazu,Tomoyuki Yoshihara,Mikio Hoshino,Shin'ichi Takeda,Chizuka Ide,Yo-ichi Nabeshima +7 more
TL;DR: A method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%, which represents a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.
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Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
Mikio Hoshino,Shoko Nakamura,Kiyoshi Mori,Kiyoshi Mori,Takeshi Kawauchi,Mami Terao,Yoshiaki V. Nishimura,Akihisa Fukuda,Toshimitsu Fuse,Naoki Matsuo,Masaki Sone,Masaki Sone,Masahiko Watanabe,Haruhiko Bito,Toshio Terashima,Christopher V.E. Wright,Yoshiya Kawaguchi,Yoshiya Kawaguchi,Kazuwa Nakao,Yo-ichi Nabeshima +19 more
TL;DR: A Cerebellar mutant, cerebelless, is described, which lacks the entire cerebellar cortex in adults and results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum.
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PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1
Takashi Nishimura,Tomoya Yamaguchi,Katsuhiro Kato,Masato Yoshizawa,Yo-ichi Nabeshima,Shigeo Ohno,Mikio Hoshino,Mikio Hoshino,Kozo Kaibuchi +8 more
TL;DR: It is proposed that the PAR-6–PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1, and that this process seems to be required for the establishment of neuronal polarity.
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Highly Efficient Green Organic Light-Emitting Diodes Containing Luminescent Three-Coordinate Copper(I) Complexes
TL;DR: A series of highly emissive three-coordinate copper(I) complexes were synthesized and investigated in prototype organic light-emitting diodes (OLEDs), showing excellent photoluminescent performance in both degassed dichloromethane solutions and amorphous films.