H
Hiroto Izumi
Researcher at Kyushu University
Publications - 16
Citations - 934
Hiroto Izumi is an academic researcher from Kyushu University. The author has contributed to research in topics: Angiogenesis & Epidermal growth factor. The author has an hindex of 10, co-authored 16 publications receiving 915 citations.
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Journal ArticleDOI
Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.
Shigeo Yoshida,Mayumi Ono,Tadahisa Shono,Hiroto Izumi,Tatsuro Ishibashi,Hideo Suzuki,Michihiko Kuwano +6 more
TL;DR: Angiogenesis by TNF-alpha appears to be modulated through various angiogenic factors, both in vitro and in vivo, and this pathway is controlled through paracrine and/or autocrine mechanisms.
Journal Article
Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine
Mayumi Ono,Naoyuki Kawahara,Daisuke Goto,Yukihiro Wakabayashi,Shin Ushiro,Shigeo Yoshida,Hiroto Izumi,Michihiko Kuwano,Yasufumi Sato +8 more
TL;DR: In vivo and in vitro assays demonstrate that irsogladine may be a unique and potent inhibitor of tumor angiogenesis.
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Inhibition of tubular morphogenesis in human microvascular endothelial cells by co-culture with chondrocytes and involvement of transforming growth factor β: a model for avascularity in human cartilage
Katsuhiro Tada,Tsutana Fukunaga,Yukihiro Wakabayashi,Shogo Masumi,Yasufumi Sato,Hiroto Izumi,Kimitoshi Kohno,Michihiko Kumano +7 more
TL;DR: This model system is the first model system demonstrating that avascularity of human chondrocytes is partly due to TGF-beta family produced from them and suggests that T GF-beta is partly involved in the human chONDrocyte-dependent inhibition of tube formation.
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Heparin‐binding Epidermal Growth Factor‐like Growth Factor: p91 Activation, Induction of Plasminogen Activator/Plasminogen Activator Inhibitor, and Tubular Morphogenesis in Human Microvascular Endothelial Cells
Shin Ushiro,Mayumi Ono,Hiroto Izumi,Kimitoshi Kohno,Naoyuki Taniguchi,Shigeki Higashiyama,Michihiko Kuwano +6 more
TL;DR: HB‐EGF developed tube‐like structures in type I collagen gel at similar levels to that of EGF at 10 ng/ml, suggesting that HB‐ EGF is also a potent angiogenic factor in the model system for angiogenesis.
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Cross Talk of Tumor Necrosis Factor-α and Epidermal Growth Factor in Human Microvascular Endothelial Cells
TL;DR: This article showed that TNF-α-induced activation of c-fos gene appears to be mediated through pleiotropic mechanisms and possibly through EGF receptor in microvascular endothelial cells.