M
Mayumi Ono
Researcher at Kyushu University
Publications - 229
Citations - 16175
Mayumi Ono is an academic researcher from Kyushu University. The author has contributed to research in topics: Angiogenesis & Cell culture. The author has an hindex of 65, co-authored 227 publications receiving 15363 citations. Previous affiliations of Mayumi Ono include Kurume University & Hokkaido University.
Papers
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Journal ArticleDOI
Interleukin-17 promotes angiogenesis and tumor growth.
Muneo Numasaki,Jun Ichi Fukushi,Mayumi Ono,Satwant K. Narula,Paul J. Zavodny,Toshio Kudo,Paul D. Robbins,Hideaki Tahara,Michael T. Lotze +8 more
TL;DR: A novel role for IL-17 is revealed as a CD4 T-cell-derived mediator of angiogenesis that stimulates vascular endothelial cell migration and cord formation and regulates production of a variety of proangiogenic factors.
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Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.
Shigeo Yoshida,Mayumi Ono,Tadahisa Shono,Hiroto Izumi,Tatsuro Ishibashi,Hideo Suzuki,Michihiko Kuwano +6 more
TL;DR: Angiogenesis by TNF-alpha appears to be modulated through various angiogenic factors, both in vitro and in vivo, and this pathway is controlled through paracrine and/or autocrine mechanisms.
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Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells POSSIBLE ROLES OF SP-1
Masahiro Ryuto,Mayumi Ono,Hiroto Izumi,Shigeo Yoshida,Herbert A. Weich,Kimitoshi Kohno,Michihiko Kuwano +6 more
TL;DR: The chloramphenicol acetyltransferase assay with VEGF promoter deletion constructs demonstrated that four clusterized SP-1 binding sites in the proximal promoter were essential for the basal transcription and the TNF-α-dependent activation.
Journal Article
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.
Akira Hirata,Soh-ichiro Ogawa,Takuro Kometani,Takashi Kuwano,Seiji Naito,Michihiko Kuwano,Mayumi Ono +6 more
TL;DR: The antitumor effects of ZD1839 could, therefore, be mediated in part by the inhibition of tumor angiogenesis through direct effects on microvascular endothelial cells that express EGFR and also through reduced production of proangiogenic factors by tumor cells.
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Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL‐1α
Hitoe Torisu,Mayumi Ono,Hiromaro Kiryu,Masutaka Furue,Yasukazu Ohmoto,Juichiro Nakayama,Yasuhiko Nishioka,Saburo Sone,Michihiko Kuwano +8 more
TL;DR: Direct evidence is found that production of the potent angiogenic factors IL‐8 and VEGF from melanoma cells is up‐regulated through TNFα and/or IL‐1α secreted by activated monocytes/macrophages, influencing both tumor growth and angiogenesis in melanomas.