H
Hitoshi Nishimura
Researcher at Nagoya University
Publications - 69
Citations - 3156
Hitoshi Nishimura is an academic researcher from Nagoya University. The author has contributed to research in topics: Interleukin 15 & CD8. The author has an hindex of 36, co-authored 69 publications receiving 3087 citations. Previous affiliations of Hitoshi Nishimura include Kōchi University.
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Journal ArticleDOI
Serum levels of IL-10, IL-15 and soluble tumour necrosis factor-alpha (TNF-α) receptors in type C chronic liver disease
Shinichi Kakumu,Akihiko Okumura,Tetsuya Ishikawa,M. Yano,Atsushi Enomoto,Hitoshi Nishimura,Kentaro Yoshioka,Yasunobu Yoshikai +7 more
TL;DR: Serum levels of these molecules correlated with disease progress in chronic HCV infection, and that IL‐10 and IL‐15 may reflect the degree of inflammation in the liver, indicate that both cytokines may be related to the development of HCC.
Journal ArticleDOI
Differential Roles of Interleukin 15 mRNA Isoforms Generated by Alternative Splicing in Immune Responses in Vivo
Hitoshi Nishimura,Toshiki Yajima,Yoshikazu Naiki,Hironaka Tsunobuchi,Masayuki Umemura,Keiko Itano,Tetsuya Matsuguchi,Misao Suzuki,Pamela S. Ohashi,Yasunobu Yoshikai +9 more
TL;DR: Two groups of IL-15 Tg mice are constructed to provide information concerning the different roles ofIL-15 isoforms in the immune system in vivo and impaired IFN-γ production upon TCR engagement.
Journal Article
IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.
Hitoshi Nishimura,Kenji Hiromatsu,Noritada Kobayashi,Kenneth H. Grabstein,Raymond J. Paxton,Kazuo Sugamura,Jeffrey A. Bluestone,Yasunobu Yoshikai +7 more
TL;DR: Results suggest that IL-15 derived from infected macrophages may contribute to the early activation of gamma delta T cells during salmonellosis.
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Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice.
Yasuji Mokuno,Tetsuya Matsuguchi,Manabu Takano,Hitoshi Nishimura,Junji Washizu,Tomohiko Ogawa,Osamu Takeuchi,Shizuo Akira,Yuji Nimura,Yasunobu Yoshikai +9 more
TL;DR: The results suggest that TLR2 is involved in the activation of canonical Vγ6/Vδ1 T cells by native E. coli lipid A in a TCR-independent manner.
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Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice
TL;DR: The results suggest that IL‐15 plays important roles in proliferation and maintenance of γδ i‐IEL.