H
Hitoshi Shimano
Researcher at University of Texas Southwestern Medical Center
Publications - 10
Citations - 4868
Hitoshi Shimano is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Sterol regulatory element-binding protein & Sterol Regulatory Element Binding Protein 1. The author has an hindex of 9, co-authored 10 publications receiving 4706 citations.
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Journal ArticleDOI
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
Hitoshi Shimano,Jay D. Horton,Robert E. Hammer,Iichiro Shimomura,Michael S. Brown,Joseph L. Goldstein +5 more
TL;DR: It is indicated that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver, owing to the engorgement of hepatocytes with cholesterol and triglycerides.
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
Hitoshi Shimano,Jay D. Horton,Iichiro Shimomura,Robert E. Hammer,Michael S. Brown,Joseph L. Goldstein +5 more
TL;DR: SRE BP-1a is the most active form of SREBP-1 and that SREbp-1c may be produced when cells require a lower rate of transcription of genes regulating cholesterol and fatty acid metabolism.
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
TL;DR: It is shown that the ratio of SREBP-1c to 1a transcripts varies markedly among organs of the adult mouse and is controlled independently by regulatory regions that respond differentially to organ-specific and metabolic factors.
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
Jay D. Horton,Iichiro Shimomura,Michael S. Brown,Robert E. Hammer,Joseph L. Goldstein,Hitoshi Shimano +5 more
TL;DR: It is concluded that SREBP-2 is a relatively selective activator of cholesterol synthesis, as opposed to fatty acid synthesis, in liver and adipose tissue of mice.
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Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
TL;DR: It is concluded that SREBPs are regulated by food consumption in the mouse liver and that the decline in nuclear SREBP-1c upon fasting may explain in part the decrease in mRNAs encoding enzymes of the fatty acid biosynthetic pathway.