H
Ho Sang Hui
Researcher at King's College London
Publications - 1
Citations - 58
Ho Sang Hui is an academic researcher from King's College London. The author has contributed to research in topics: Protein aggregation & Neurodegeneration. The author has an hindex of 1, co-authored 1 publications receiving 36 citations.
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RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy.
Han-Jou Chen,Han-Jou Chen,Simon Topp,Ho Sang Hui,Elsa Zacco,Malvika Katarya,Conor McLoughlin,Andrew David King,Bradley N. Smith,Claire Troakes,Annalisa Pastore,Christopher Shaw,Christopher Shaw +12 more
TL;DR: It is reported that mutated forms of TDP-43 that are unable to bind RNA have an increased tendency to aggregate, and can mediate toxicity by sequestering wild-type TPD-43.