H
Hoang-Oanh B. Nguyen
Researcher at University of California, San Francisco
Publications - 12
Citations - 2748
Hoang-Oanh B. Nguyen is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Amyloid & Scrapie. The author has an hindex of 12, co-authored 12 publications receiving 2664 citations.
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Journal ArticleDOI
Synthetic Mammalian Prions
Giuseppe Legname,Ilia V. Baskakov,Hoang-Oanh B. Nguyen,Detlev Riesner,Fred E. Cohen,Stephen J. DeArmond,Stanley B. Prusiner +6 more
TL;DR: The results provide compelling evidence that prions are infectious proteins and suggest that a novel prion strain was created.
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Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.
Michael R. Scott,Robert G. Will,James W. Ironside,Hoang-Oanh B. Nguyen,Patrick Tremblay,Stephen J. DeArmond,Stanley B. Prusiner +6 more
TL;DR: It is reported that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(Bo PrP) mice.
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Elimination of prions by branched polyamines and implications for therapeutics
Surachai Supattapone,Hoang-Oanh B. Nguyen,Frederick Cohen,Stanley B. Prusiner,Michael R. Scott +4 more
TL;DR: Branched polyamines, including polyamidoamide dendimers, polypropyleneimine, and polyethyleneimine are able to purge PrP(Sc), the protease-resistant isoform of the prion protein, from scrapie-infected neuroblastoma (ScN2a) cells in culture.
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Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
Giuseppe Legname,Hoang-Oanh B. Nguyen,David Peretz,Frederick Cohen,Stephen J. DeArmond,Stanley B. Prusiner +5 more
TL;DR: It is demonstrated that less stable prions replicate more rapidly than do stablePrPSc molecules, and cellular machinery must exist for propagating a large number of different PrPSc conformers, each of which enciphers a distinct biological phenotype as reflected by a specific incubation time.
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Strain-specified characteristics of mouse synthetic prions
Giuseppe Legname,Hoang-Oanh B. Nguyen,Ilia V. Baskakov,Frederick Cohen,Stephen J. DeArmond,Stanley B. Prusiner +5 more
TL;DR: The incubation times, neuropathological lesion profiles, and Gdn1/2 values indicate that MoSP1 prions differ from RML and many other prion strains derived from sheep with scrapie and cattle with bovine spongiform encephalopathy.