J
James W. Ironside
Researcher at University of Edinburgh
Publications - 592
Citations - 35714
James W. Ironside is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Bovine spongiform encephalopathy & PRNP. The author has an hindex of 86, co-authored 590 publications receiving 33745 citations. Previous affiliations of James W. Ironside include St Mary's Hospital & Western General Hospital.
Papers
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Journal ArticleDOI
A new variant of Creutzfeldt-Jakob disease in the UK
Robert G. Will,James W. Ironside,M. Zeidler,Simon Cousens,K Estibeiro,Annick Alpérovitch,Sigrid Poser,Maurizio Pocchiari,Albert Hofman,Pete Smith +9 more
TL;DR: Ten cases of Creutzfeldt-Jakob disease have been identified in the UK in recent months with a new neuropathological profile that raises the possibility that they are causally linked to BSE.
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Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent
Moira E. Bruce,Robert G. Will,James W. Ironside,I. McConnell,D. Drummond,A. Suttie,L. McCardle,A. Chree,James Hope,Christopher R. Birkett,Simon Cousens,H. Fraser,Christopher J. Bostock +12 more
TL;DR: It is shown that the strain of agent from cattle affected by bovine spongiform encephalopathy (BSE) produces a characteristic pattern of disease in mice that is retained after experimental passage through a variety of intermediate species, providing strong evidence that the same agent strain is involved in both BSE and vCJD.
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Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
TL;DR: Strain characteristics revealed here suggest that the prion protein may itself encode disease phenotype, consistent with BSE being the source of this new disease.
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Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples
Andrew F. Hill,RJ Butterworth,Susan Joiner,Graham S. Jackson,Martin N. Rossor,Dafydd Thomas,Adam Frosh,N Tolley,JE Bell,Michael D. Spencer,Andrew T. King,S Al-Sarraj,James W. Ironside,Peter L. Lantos,John Collinge +14 more
TL;DR: If, in the appropriate clinical context, a tonsil biopsy sample was positive for PrPSc, variant CJD could be diagnosed, which obviates the need for a brainBiopsy sample to be taken, and the results show that variants CJD has a different pathogenesis to sporadic CJD.
Journal ArticleDOI
Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.
Michael R. Scott,Robert G. Will,James W. Ironside,Hoang-Oanh B. Nguyen,Patrick Tremblay,Stephen J. DeArmond,Stanley B. Prusiner +6 more
TL;DR: It is reported that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(Bo PrP) mice.