Hoe Suk Kim

TL;DR: This work presents discrete, monodisperse, and precisely sizecontrollable core–shell mesoporous silica NPs smaller than 100 nm by using single Fe3O4 nanocrystals as cores (designated as Fe3 O4@mSiO2) and demonstrates the multifunctional bioapplications of the core-shell NPs for simultaneous magnetic resonance and fluorescence imaging, and for drug delivery.

TL;DR: Results suggest breast cancer cell-derived exosomes stimulate macrophage polarization that creates favorable conditions for LN metastatic processes in TNBC.

TL;DR: The data demonstrate a mechanism in which the miR-141/200c cluster, through FAK- and PI3K/AKT-mediated signaling by means of increased VEGF-A secretion, promotes the migratory and invasive abilities of MDA-MB-231 cells.

TL;DR: It is demonstrated that SerpinB2 promotes miR-200c/141 cluster overexpression-induced breast cancer cell metastasis, and Ser pinB2 overexposure correlates with increased metastatic potential and unfavorable outcomes in breast cancer patients.

TL;DR: It is demonstrated that weak LOXL4 expression leads to remodeling of the extracellular matrix through induction of collagen synthesis, deposition, and structural changes and is associated with poor clinical outcomes in triple-negative breast cancer.