Embracing imperfect datasets: A review of deep learning solutions for medical image segmentation

Scene understanding of high resolution aerial images is of great importance for the task of automated monitoring in various remote sensing applications. Due to the large within-class and small between-class variance in pixel values of objects of interest, this remains a challenging task. In recent years, deep convolutional neural networks have started being used in remote sensing applications and demonstrate state of the art performance for pixel level classification of objects. Here we propose a reliable framework for performant results for the task of semantic segmentation of monotemporal very high resolution aerial images. Our framework consists of a novel deep learning architecture, ResUNet-a , and a novel loss function based on the Dice loss. ResUNet-a uses a UNet encoder/decoder backbone, in combination with residual connections, atrous convolutions, pyramid scene parsing pooling and multi-tasking inference. ResUNet-a infers sequentially the boundary of the objects, the distance transform of the segmentation mask, the segmentation mask and a colored reconstruction of the input. Each of the tasks is conditioned on the inference of the previous ones, thus establishing a conditioned relationship between the various tasks, as this is described through the architecture’s computation graph. We analyse the performance of several flavours of the Generalized Dice loss for semantic segmentation, and we introduce a novel variant loss function for semantic segmentation of objects that has excellent convergence properties and behaves well even under the presence of highly imbalanced classes. The performance of our modeling framework is evaluated on the ISPRS 2D Potsdam dataset. Results show state-of-the-art performance with an average F1 score of 92.9% over all classes for our best model.

ResUNet-a: A deep learning framework for semantic segmentation of remotely sensed data

U-net is an image segmentation technique developed primarily for image segmentation tasks. These traits provide U-net with a high utility within the medical imaging community and have resulted in extensive adoption of U-net as the primary tool for segmentation tasks in medical imaging. The success of U-net is evident in its widespread use in nearly all major image modalities, from CT scans and MRI to X-rays and microscopy. Furthermore, while U-net is largely a segmentation tool, there have been instances of the use of U-net in other applications. Given that U-net’s potential is still increasing, this narrative literature review examines the numerous developments and breakthroughs in the U-net architecture and provides observations on recent trends. We also discuss the many innovations that have advanced in deep learning and discuss how these tools facilitate U-net. In addition, we review the different image modalities and application areas that have been enhanced by U-net.

U-Net and Its Variants for Medical Image Segmentation: A Review of Theory and Applications

The semantic image segmentation task consists of classifying each pixel of an image into an instance, where each instance corresponds to a class. This task is a part of the concept of scene understanding or better explaining the global context of an image. In the medical image analysis domain, image segmentation can be used for image-guided interventions, radiotherapy, or improved radiological diagnostics. In this review, we categorize the leading deep learning-based medical and non-medical image segmentation solutions into six main groups of deep architectural, data synthesis-based, loss function-based, sequenced models, weakly supervised, and multi-task methods and provide a comprehensive review of the contributions in each of these groups. Further, for each group, we analyze each variant of these groups and discuss the limitations of the current approaches and present potential future research directions for semantic image segmentation.

Deep semantic segmentation of natural and medical images: a review

Since its renaissance, deep learning (DL) has been widely used in various medical imaging tasks and has achieved remarkable success in many medical imaging applications, thereby propelling us into the so-called artificial intelligence (AI) era. It is known that the success of AI is mostly attributed to the availability of big data with annotations for a single task and the advances in high-performance computing. However, medical imaging presents unique challenges that confront DL approaches. In this survey article, we first present traits of medical imaging, highlight both clinical needs and technical challenges in medical imaging, and describe how emerging trends in DL are addressing these issues. We cover the topics of network architecture, sparse and noisy labels, federating learning, interpretability, uncertainty quantification, and so on. Then, we present several case studies that are commonly found in clinical practice, including digital pathology and chest, brain, cardiovascular, and abdominal imaging. Rather than presenting an exhaustive literature survey, we instead describe some prominent research highlights related to these case study applications. We conclude with a discussion and presentation of promising future directions.

A Review of Deep Learning in Medical Imaging: Imaging Traits, Technology Trends, Case Studies With Progress Highlights, and Future Promises

Constrained-CNN losses for weakly supervised segmentation.

Widely used loss functions for CNN segmentation, e.g., Dice or cross-entropy, are based on integrals over the segmentation regions. Unfortunately, for highly unbalanced segmentations, such regional summations have values that differ by several orders of magnitude across classes, which affects training performance and stability. We propose a boundary loss, which takes the form of a distance metric on the space of contours, not regions. This can mitigate the difficulties of highly unbalanced problems because it uses integrals over the interface between regions instead of unbalanced integrals over the regions. Furthermore, a boundary loss complements regional information. Inspired by graph-based optimization techniques for computing active-contour flows, we express a non-symmetric L2 distance on the space of contours as a regional integral, which avoids completely local differential computations involving contour points. This yields a boundary loss expressed with the regional softmax probability outputs of the network, which can be easily combined with standard regional losses and implemented with any existing deep network architecture for N-D segmentation. We report comprehensive evaluations and comparisons on different unbalanced problems, showing that our boundary loss can yield significant increases in performances while improving training stability. Our code is publicly available1.

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Boundary loss for highly unbalanced segmentation

Boundary loss for highly unbalanced segmentation.

We show that the way inference is performed in few-shot segmentation tasks has a substantial effect on performances -- an aspect often overlooked in the literature in favor of the meta-learning paradigm. We introduce a transductive inference for a given query image, leveraging the statistics of its unlabeled pixels, by optimizing a new loss containing three complementary terms: i) the cross-entropy on the labeled support pixels; ii) the Shannon entropy of the posteriors on the unlabeled query-image pixels; and iii) a global KL-divergence regularizer based on the proportion of the predicted foreground. As our inference uses a simple linear classifier of the extracted features, its computational load is comparable to inductive inference and can be used on top of any base training. Foregoing episodic training and using only standard cross-entropy training on the base classes, our inference yields competitive performances on standard benchmarks in the 1-shot scenarios. As the number of available shots increases, the gap in performances widens: on PASCAL-5i, our method brings about 5% and 6% improvements over the state-of-the-art, in the 5- and 10-shot scenarios, respectively. Furthermore, we introduce a new setting that includes domain shifts, where the base and novel classes are drawn from different datasets. Our method achieves the best performances in this more realistic setting. Our code is freely available online: this https URL.

Few-Shot Segmentation Without Meta-Learning: A Good Transductive Inference Is All You Need?

We propose a novel weakly supervised learning segmentation based on several global constraints derived from box annotations. Particularly, we leverage a classical tightness prior to a deep learning setting via imposing a set of constraints on the network outputs. Such a powerful topological prior prevents solutions from excessive shrinking by enforcing any horizontal or vertical line within the bounding box to contain, at least, one pixel of the foreground region. Furthermore, we integrate our deep tightness prior with a global background emptiness constraint, guiding training with information outside the bounding box. We demonstrate experimentally that such a global constraint is much more powerful than standard cross-entropy for the background class. Our optimization problem is challenging as it takes the form of a large set of inequality constraints on the outputs of deep networks. We solve it with sequence of unconstrained losses based on a recent powerful extension of the log-barrier method, which is well-known in the context of interior-point methods. This accommodates standard stochastic gradient descent (SGD) for training deep networks, while avoiding computationally expensive and unstable Lagrangian dual steps and projections. Extensive experiments over two different public data sets and applications (prostate and brain lesions) demonstrate that the synergy between our global tightness and emptiness priors yield very competitive performances, approaching full supervision and outperforming significantly DeepCut. Furthermore, our approach removes the need for computationally expensive proposal generation. Our code is shared anonymously.

/pdf/bounding-boxes-for-weakly-supervised-segmentation-global-58yj2npo93.pdf

Hoel Kervadec

Papers

Constrained-CNN losses for weakly supervised segmentation.

Boundary loss for highly unbalanced segmentation

Boundary loss for highly unbalanced segmentation.

Few-Shot Segmentation Without Meta-Learning: A Good Transductive Inference Is All You Need?

Bounding boxes for weakly supervised segmentation: Global constraints get close to full supervision