H
Hojoon Lee
Researcher at Seoul National University
Publications - 17
Citations - 1084
Hojoon Lee is an academic researcher from Seoul National University. The author has contributed to research in topics: Chordin & Xenopus. The author has an hindex of 10, co-authored 15 publications receiving 933 citations. Previous affiliations of Hojoon Lee include University of California, Los Angeles & Columbia University.
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Journal ArticleDOI
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Franck Oury,Lori Khrimian,Christine A. Denny,Antoine Gardin,Alexandre Chamouni,Nick Goeden,Yung Yu Huang,Hojoon Lee,Prashanth Srinivas,Xiao-Bing Gao,Shigetomo Suyama,Thomas Langer,J. John Mann,Tamas L. Horvath,Alexandre Bonnin,Gerard Karsenty +15 more
TL;DR: It is shown that the osteoblast-derived hormone osteocalcin crosses the blood-brain barrier, binds to neurons of the brainstem, midbrain, and hippocampus, enhances the synthesis of monoamine neurotransmitters, inhibits GABA synthesis, prevents anxiety and depression, and favors learning and memory independently of its metabolic functions.
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Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.
TL;DR: An unexpected role for the secreted Frizzled-related protein (sFRP) Sizzled/Ogon as an inhibitor of the extracellular proteolytic reaction that controls BMP signaling during Xenopus gastrulation is reported.
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Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos
TL;DR: The authors showed that BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
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Crossveinless-2 Is a BMP Feedback Inhibitor that Binds Chordin/BMP to Regulate Xenopus Embryonic Patterning
Andrea L. Ambrosio,Vincent F. Taelman,Hojoon Lee,Carrie A. Metzinger,Catherine Coffinier,E. M. De Robertis +5 more
TL;DR: It is proposed that the CV2/Chordin interaction may help coordinate BMP diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.
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Rewiring the taste system
TL;DR: The basic logic of the wiring of the taste system at the periphery is uncovered, and how a labelled-line sensory circuit preserves signalling integrity despite rapid and stochastic turnover of receptor cells is illustrated.