Hong Jiang

TL;DR: The results provide a possible new therapeutic target and paradigm for NO restoration in humans by specific oral bacteria, and may also provide mechanistic evidence for the oral systemic link.

TL;DR: It is suggested that nitrite improves insulin signaling through restoration of NO-dependent nitrosation of GLUT4 signaling translocation and may justify a high-nitrate/nitrite diet along with the glycemic index to provide a safe and nutritional regimen for the management and treatment of diabetes.

TL;DR: The collective body of evidence suggests that foods enriched in nitrite and nitrate provide significant health benefits with very little risk, contradict decades of epidemiological research that have suggested an association of nitrites in foods, primarily cured and processed meat, with certain cancers.

TL;DR: It is shown that the urea cycle disorder, argininosuccinate lyase deficiency (ASLD), can manifest as a Mendelian form of endothelial-dependent hypertension and that ASLD is a unique model for studying NO-dependent endothelial dysfunction in human hypertension.

TL;DR: The results suggest that sodium nitrite improves motor function in old mice, in part by reducing low-grade inflammation in muscle.