Hong-Kun Wu

TL;DR: It is shown that receptor-interacting protein 3 (RIP3) triggers myocardial necroptosis, in addition to apoptosis and inflammation, through activation of Ca2+-calmodulin–dependent protein kinase (CaMKII) rather than through the well-established RIP3 partners RIP1 and MLKL.

TL;DR: In this article, muscle-specific mitsugumin 53 (MG53; also called TRIM72) mediates the degradation of the insulin receptor and insulin receptor substrate 1 (IRS1), and when upregulated, causes metabolic syndrome featuring insulin resistance, obesity, hypertension and dyslipidaemia.

TL;DR: It is discovered that baicalin acts as a natural allosteric activator of carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme of fatty acid β-oxidation (FAO), the controlling enzyme for fatty acid oxidation.

TL;DR: It is demonstrated that MG53 is a glucose-sensitive myokine/cardiokine that governs the interorgan regulation of insulin sensitivity and that Targeting circulating MG53 opens a new therapeutic avenue for T2DM and its complications.

TL;DR: It is concluded that IPC and oxidative stress can trigger MG53 secretion from the heart via an H2O2–protein kinase-C-δ–dependent mechanism and that extracellular MG53 can participate in IPC protection against cardiac ischemia/reperfusion injury.